SIRT6, sirtuin 6, 51548

N. diseases: 195; N. variants: 2
Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 Biomarker disease BEFREE Further investigation of the mechanism involved revealed that cyanidin could upregulate the Sirt6 level in a dose-dependent manner and Sirt6 silencing abolished the effect of cyanidin in IL-1β-stimulated human OA chondrocytes, indicating a stimulatory effect of cyanidin on Sirt6 activation. 31464310 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 AlteredExpression disease BEFREE Lastly, PBMCs and monocytes/macrophages from RA patients exhibited lower expression of Sirt6 than those from patients with osteoarthritis, and their Sirt6 activity was inversely correlated with disease severity. 30429089 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 Biomarker disease BEFREE Sirtuin 6 (SIRT6) has also been demonstrated to prevent OA development by reducing both the inflammatory response and chondrocyte senescence. 29286133 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 AlteredExpression disease BEFREE We found sirt6 level was significantly decreased in the articular chondrocytes of OA patients compare to normal human. 26639398 2015