Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Because COL1A1 exon 29 has been involved previously in gene fusion with PDGFB exon 2 in several cases of adult or infantile DP presenting either t(17;22) or ring chromosomes, our results support the concept that DP, GCF, and BT are morphologic variants of a same entity, rather than distinct tumors.
|
12034531 |
2002 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In one tumor cell line, which expressed high PDGF-2 mRNA levels, the presence of the positive regulatory region resulted in a 30-fold increase in promoter activity.
|
2651898 |
1989 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To confirm the diagnosis, molecular studies were performed on fixed tumor and revealed the presence of the fusion product of the COL1A1-PDGFB genes characteristic of DFSP.
|
12660034 |
2003 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although PDGFB has been implicated in transforming processes via autocrine and paracrine pathways, by the activation of the cognate receptor, no direct evidence of its involvement in neoplastic transformation of human tumours has been so far provided.
|
9771975 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results presented indicated that TGF beta 2, TGF alpha, and bFGF may be particularly important in melanomagenesis and that these, as well as FGF-5, aFGF, and PDGFB, can be used as markers of transformation in this tumor type.
|
1716514 |
1991 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The PDGFB copy number showed a moderate positive correlation with the number of mitotic figures and tumor size.
|
23347652 |
2013 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data support a model in which low levels of sis gene expression in tumors contribute to the acquisition of some features of transformation but require complementation by other genes or factors to produce a fully malignant phenotype.
|
1323300 |
1992 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We also show that infecting brainstem glial progenitors with PDGFB-green fluorescent protein (GFP)-expressing retrovirus induced tumors that closely resembled human malignant gliomas.
|
20468047 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumors that contained a high level of PDGF B-chain showed high proliferative activity, while tumors with high proliferative activity did not always contain a high level of PDGF B-chain.
|
7685850 |
1993 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PDGFB can mediate the development of mouse spinal tumors that are histologically and pathologically indistinguishable from primary intramedullary spinal tumors of humans and may provide opportunities for both novel insights into the pathogenesis of these tumors and the development of new therapeutics.
|
18922925 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Genetic aberrations involving the platelet-derived growth factor-beta (PDGFB) gene and the collagen type 1 alpha1 (COL1A1) gene have been implicated in the pathogenesis of dermatofibrosarcoma protuberans (DFSP), a slow-growing and locally infiltrative dermal tumour.
|
19663837 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although rare, the existence of cases of DFSP negative for the COL1A1-PDGFB fusion has to be taken in consideration when performing molecular diagnosis for a tumor suspected to be a DFSP.
|
18253748 |
2008 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
As the mechanism for activation of expression of the c-sis gene in gliomas is not known, we searched for possible structural alterations of c-sis DNA in these tumors.
|
2585029 |
1989 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PDGFB-overexpressing and NF1-silenced murine tumors closely cluster with human proneural and mesenchymal subtypes, as well as PDGFRA-amplified and NF1-deleted/mutant human tumors, respectively, at both the RNA and protein expression levels.
|
28836293 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The COL1A1-PDGFB fusion transcript was detected from the tumour specimen.
|
12786837 |
2003 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, unlike oncogenes such as PDGFB or ras, Wnt-1 and -2 failed to induce detectable transformed foci following transfection, and stable NIH3T3 transfectants lacked tumor forming capacity.
|
9652750 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor cells are reactive for CD34 and characterized by a t(17;22) translocation or a supernumerary ring chromosome that results in the fusion of exon 2 of PDGFB to various exons of the COL1A1 gene.
|
17950782 |
2008 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This is the first case of DFSP showing such a fusion point, which is intriguingly identical to that found in a GCF case, indicating that the COL1A1/PDGFB fusion point position does not seem to affect tumor morphology.
|
10963386 |
2000 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Rare examples of vulvar DFSP have been reported, including myxoid, myoid, and fibrosarcomatous variants, but detection of the characteristic t(17;22)(q22;q13) that produces COL1A1-PDGFB gene fusion has not been evaluated in a large series of primary vulvar tumors.
|
29140881 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, Cav3.2 inhibition decreased expression of oncogenes (PDGFA, PDGFB, and TGFB1) and increased expression of tumor suppressor genes (TNFRSF14 and HSD17B14).
|
28512247 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Molecular analysis of one of the cases showed a characteristic COL1A1-PDGFB rearrangement in both the main tumor and also in the cells lining the pseudocystic portion of the tumor, confirming the diagnosis and indicating that the lining represented a component of the proliferation.
|
22335595 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of the data from the 8 tumor samples showed that amplifications of TP73 (1p36.33), SNRPN (15q12), and PDGFB (22q13.1) occurred exclusively in tumors with a wild type BRAF.
|
17227125 |
2007 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the 20 paired samples, the PDGFB gene amplification in the tumor was significantly higher than that in the normal tissue.
|
17431412 |
2007 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results strongly suggest that the COL1A1-PDGFB chimeric gene expression associated with DP, induces tumours formation through production of mature PDGFB, in an autocrine or paracrine way.
|
11420709 |
2001 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Median tumor latency was shorter in mice injected with PDGFB and Bcl-2 compared to those injected with PDGFB alone.
|
21171016 |
2011 |