Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.
|
3754619 |
1986 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, the tumor cells expressed more mRNA for PDGF A chain than for PDGF B chain and PDGF receptor.
|
2845420 |
1988 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In one tumor cell line, which expressed high PDGF-2 mRNA levels, the presence of the positive regulatory region resulted in a 30-fold increase in promoter activity.
|
2651898 |
1989 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
As the mechanism for activation of expression of the c-sis gene in gliomas is not known, we searched for possible structural alterations of c-sis DNA in these tumors.
|
2585029 |
1989 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results presented indicated that TGF beta 2, TGF alpha, and bFGF may be particularly important in melanomagenesis and that these, as well as FGF-5, aFGF, and PDGFB, can be used as markers of transformation in this tumor type.
|
1716514 |
1991 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data support a model in which low levels of sis gene expression in tumors contribute to the acquisition of some features of transformation but require complementation by other genes or factors to produce a fully malignant phenotype.
|
1323300 |
1992 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumors that contained a high level of PDGF B-chain showed high proliferative activity, while tumors with high proliferative activity did not always contain a high level of PDGF B-chain.
|
7685850 |
1993 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PDGF B chain and PDGFR were detected in 18 (66.7%) and 20 (74.1%), respectively, and ER mRNA was observed in 16 (59.3%) tumors.
|
8491760 |
1993 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results clearly support a role of c-sis protein in the proliferation of these human neuroglial tumors and show that inducible protein expression can be blocked by means of synthetic oligonucleotides complementary to a coding exon.
|
8177392 |
1994 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although PDGFB has been implicated in transforming processes via autocrine and paracrine pathways, by the activation of the cognate receptor, no direct evidence of its involvement in neoplastic transformation of human tumours has been so far provided.
|
9771975 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, unlike oncogenes such as PDGFB or ras, Wnt-1 and -2 failed to induce detectable transformed foci following transfection, and stable NIH3T3 transfectants lacked tumor forming capacity.
|
9652750 |
1998 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This is the first case of DFSP showing such a fusion point, which is intriguingly identical to that found in a GCF case, indicating that the COL1A1/PDGFB fusion point position does not seem to affect tumor morphology.
|
10963386 |
2000 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As the chimeric gene, COL1A1-PDGFB, has been proposed to play an important role in the histogenesis of DFSP, we conducted a reverse transcription-polymerase chain reaction assay to ascertain whether the COL1A1-PDGFB fusion transcripts can be detected in both conventional DFSP and fibrosarcomatous components of DFSP with fibrosarcomatous areas (DFSP-FS), using a simple method of microdissection on sections of archival formalin-fixed, paraffin-embedded tumor specimens from six DFSP-FS cases.
|
11272901 |
2000 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results strongly suggest that the COL1A1-PDGFB chimeric gene expression associated with DP, induces tumours formation through production of mature PDGFB, in an autocrine or paracrine way.
|
11420709 |
2001 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Because COL1A1 exon 29 has been involved previously in gene fusion with PDGFB exon 2 in several cases of adult or infantile DP presenting either t(17;22) or ring chromosomes, our results support the concept that DP, GCF, and BT are morphologic variants of a same entity, rather than distinct tumors.
|
12034531 |
2002 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To confirm the diagnosis, molecular studies were performed on fixed tumor and revealed the presence of the fusion product of the COL1A1-PDGFB genes characteristic of DFSP.
|
12660034 |
2003 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The COL1A1-PDGFB fusion transcript was detected from the tumour specimen.
|
12786837 |
2003 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of the data from the 8 tumor samples showed that amplifications of TP73 (1p36.33), SNRPN (15q12), and PDGFB (22q13.1) occurred exclusively in tumors with a wild type BRAF.
|
17227125 |
2007 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the 20 paired samples, the PDGFB gene amplification in the tumor was significantly higher than that in the normal tissue.
|
17431412 |
2007 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PDGFB can mediate the development of mouse spinal tumors that are histologically and pathologically indistinguishable from primary intramedullary spinal tumors of humans and may provide opportunities for both novel insights into the pathogenesis of these tumors and the development of new therapeutics.
|
18922925 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although rare, the existence of cases of DFSP negative for the COL1A1-PDGFB fusion has to be taken in consideration when performing molecular diagnosis for a tumor suspected to be a DFSP.
|
18253748 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor cells are reactive for CD34 and characterized by a t(17;22) translocation or a supernumerary ring chromosome that results in the fusion of exon 2 of PDGFB to various exons of the COL1A1 gene.
|
17950782 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We also show that infecting brainstem glial progenitors with PDGFB-green fluorescent protein (GFP)-expressing retrovirus induced tumors that closely resembled human malignant gliomas.
|
20468047 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Genetic aberrations involving the platelet-derived growth factor-beta (PDGFB) gene and the collagen type 1 alpha1 (COL1A1) gene have been implicated in the pathogenesis of dermatofibrosarcoma protuberans (DFSP), a slow-growing and locally infiltrative dermal tumour.
|
19663837 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Median tumor latency was shorter in mice injected with PDGFB and Bcl-2 compared to those injected with PDGFB alone.
|
21171016 |
2011 |