|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-23 plays an important role in the development of arthritis and the IL-23 receptor (IL-23R) is expressed on different types of T cells.
|
31778214 |
2020 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-23 is thought to promote joint destruction in arthritis by stimulating Th17 cells.
|
29414600 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-23/T helper 17 (Th17) axis plays an important role in joint inflammation in ankylosing spondylitis (AS).
|
30057583 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To define the contribution of γδ T cells in the pathogenesis of inflammatory arthritis, we performed gene transfer of IL-23 in B10.RIII mice to establish joint inflammation in the presence or absence of γδ T cells.
|
29765156 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, we used IL-23 in vivo gene transfer to induce arthritis in mice and showed that elevated serum LTB<sub>4</sub> and synovial expression of 5-lipoxygenase correlated with increased disease severity by histological evaluation and paw swelling compared with GFP gene transfer controls.
|
27895169 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the IL-23/Th17 pathway is a therapeutic target for the treatment of inflammatory arthritis.
|
28850053 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, compared with anti-p40 treatment, 2305 effectively and selectively inhibits IL-23-induced inflammation in three in vivo mouse models: IL-23-induced ear inflammation, anti-CD40-induced systemic inflammatory response, and collagen-induced arthritis.
|
25354400 |
2014 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
BALB/c wild type (WT), IL-12p40-/- and IL-23p19-/- littermate mice were immunized with recombinant G1 (rG1) domain of human PG in adjuvant either i.p. or s.c. and development of arthritis monitored.Joint histology was assessed.
|
25253467 |
2014 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, our data suggest that systemic IL-23 exposure induces the expansion of a myeloid lineage osteoclast precursor, and targeting IL-23 pathway may combat inflammation-driven bone destruction as observed in rheumatoid arthritis and other autoimmune arthritides.
|
21670317 |
2011 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, IL-23 appears to induce joint inflammation and bone destruction by stimulating RANKL expression in RA-FLS.
|
19900478 |
2010 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several studies suggest that IL-23 is an essential promoter of chronic joint inflammation.
|
19034457 |
2009 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that IL-23 is important in human osteoclastogenesis and that neutralizing IL-23 after onset of collagen-induced arthritis has therapeutic potential.
|
17888176 |
2007 |