|
Dermatitis, Atopic
|
0.090 |
Biomarker
|
disease |
BEFREE |
IL-17C was depleted using a new IL-17C specific antibody (MOR106) in murine models of psoriasis (IL-23 injection model) and AE (MC903 model) as well as in human skin biopsies of psoriasis and AE.
|
31793105 |
2020 |
|
Dermatitis, Atopic
|
0.090 |
Biomarker
|
disease |
BEFREE |
Evidence that AD is driven by multiple immune axes extending beyond the Th2 polarization has resulted in therapies targeting additional pathways, including the Th22, Th17/IL-23, and JAK-STAT pathways.
|
30672355 |
2019 |
|
Dermatitis, Atopic
|
0.090 |
Biomarker
|
disease |
BEFREE |
Ustekinumab, a human monoclonal IgG1 antibody targeting the p40-subunit shared by interleukin (IL)12 and IL-23, represents a potential treatment for atopic dermatitis (AD).
|
29164954 |
2018 |
|
Dermatitis, Atopic
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Although AD is predominantly associated with type 2 immune responses, activation of other cytokine pathways including T<sub>H</sub>1, T<sub>H</sub>22, and T<sub>H</sub>17/IL-23 has been reported, suggesting potential therapeutic targets and provide a rationale for treatment with novel biologics.
|
29122151 |
2018 |
|
Dermatitis, Atopic
|
0.090 |
Biomarker
|
disease |
BEFREE |
IL-23-injected, NC/Nga, and oxazolone-challenged mice show the largest homology with our human meta-analysis-derived AD transcriptome (37%, 18%, 17%, respectively).
|
27702671 |
2017 |
|
Dermatitis, Atopic
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
AD-MSCs showed an upregulation of many Th1/Th17 cytokines [interleukin (IL)-6, IL-8, IL-12, IL-13, IL-17A, IL-17F, transforming growth factor-β, interferon-γ], while Th2 chemokines (IL-2, IL-4, IL-5, IL-23A) were downregulated in AD-MSCs.
|
27639070 |
2017 |
|
Dermatitis, Atopic
|
0.090 |
Biomarker
|
disease |
BEFREE |
Studies have found that the interleukin-23/T helper 17 (IL-23/Th17) pathway plays an important role in the pathogenesis of atopic dermatitis (AD).
|
25223230 |
2015 |
|
Dermatitis, Atopic
|
0.090 |
Biomarker
|
disease |
BEFREE |
IL-23 induces atopic dermatitis-like inflammation instead of psoriasis-like inflammation in CCR2-deficient mice.
|
23472158 |
2013 |
|
Dermatitis, Atopic
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
As the IFN-gamma-inducing cytokines IL-12 and IL-23 utilize IL-12Rbeta1 as part of their receptors, it is possible that polymorphic variants of the IL-12Rbeta1 (IL12RB1) gene might determine an individual's susceptibility to AD.
|
16159888 |
2005 |