TDP2, tyrosyl-DNA phosphodiesterase 2, 51567

N. diseases: 65; N. variants: 6
Disease: Multiple Chronic Conditions ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3266262
Disease: Multiple Chronic Conditions
Multiple Chronic Conditions 		0.020 Biomarker disease BEFREE TTRAP is a multi-functional protein that is involved in multiple aspects of cellular functions including cell proliferation, apoptosis and the repair of DNA damage. 23433115 2013
CUI: C3266262
Disease: Multiple Chronic Conditions
Multiple Chronic Conditions 		0.020 Biomarker disease BEFREE Emerging data suggest that EAPII is a multi-functional protein: EAPII repairs enzyme (topoisomerase)-mediated DNA damage by removing phosphotyrosine from DNA adducts; EAPII is involved in multiple signal transduction pathways such as TNF-TNFR, TGFβ and MAPK, and EAPII is responsive to immune defense, inflammatory response, virus infection and DNA toxins (chemo or radiation therapy). 21926483 2011