Immunoreactivity was compared between control and AD groups for neuropathological hallmarks (amyloid-β, tau, ubiquitin), Purkinje cells (calbindin), microglia (IBA1, HLA-DR), astrocytes (GFAP) basement-membrane associated molecules (fibronectin, collagen IV), endothelial cells (CD31/PECAM-1) and mural cells (PDGFRβ, αSMA).
However, pericytes isolated from transgenic AD mice differentiated into CD11b<sup>+</sup> microglia (Type A, <10%) without addition of exogenous differentiation factors, displayed moderate Iba1<sup>+</sup> immunostaining and phagocytic activity, but were still positive for PDGFRβ.