Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tif1γ can function as an oncogene and as a tumor suppressor.
|
30896800 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, TIF1γ can function either as a tumor suppressor or promoter in different cellular contexts, yet there are few reviews focusing on the roles of TIF1γ in cancer.
|
31632911 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transcription intermediary factor 1γ (ΤΙF1γ) protein is known as a tumour suppressor that promotes cellular differentiation.
|
29745874 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo VPA also showed its anti-growth effect including tumor growth and EMT mediated by TIF1γ coincide with in vitro experiments.
|
31323225 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These genetic alterations, in the context of a high expression of TIF1γ in the tumour, muscle and skin of these patients may be key to understanding the genesis of paraneoplastic myositis.
|
29149307 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CD73 is an ecto-enzyme that promotes tumor immune escape through the production of immunosuppressive extracellular adenosine in the tumor microenvironment.
|
29145561 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, immunohistochemical staining demonstrated that transforming growth factor‑β (TGF‑β) and low expression of SMAD4 was associated with a lower Fuhrman grade and low expression of transcription intermediary factor 1‑γ was associated with a higher tumor Fuhrman grade (P<0.05), Therefore, based on the regulatory effect of SMAD4 on EMT‑associated transcription factors, SMAD4 which can form a SMAD3/SMAD4 complex induced by TGF‑β, could be a potential anticancer drug target inhibiting tumor invasion and metastasis in RCC.
|
28901475 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transcription accessory factor TIF1γ/TRIM33/RFG7/PTC7/Ectodermin functions as a tumor suppressor that promotes development and cellular differentiation.
|
26282171 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TRIM33 is identified here as a lineage dependency in B cell neoplasms and is shown to perform this essential function by associating with a single cis element.
|
25919951 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Amplification of eight genes (PIK3CA, EGFR, CCND2, KDM5A, ERBB2, PMS1, FGFR1, and WHSCIL1) and deletion of five genes (CDKN2A, SMAD4, NOTCH2, NRAS, and TRIM33) were found in both HNSCC cell lines and tumors.
|
24425785 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these results demonstrate that TIF1G is an epigenetically regulated tumor suppressor gene in hematopoietic cells and suggest that changes in TIF1γ expression may be a biomarker of response to demethylating agents in CMML.
|
21537084 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mutations in ASXL1, TET2, AML1, NRAS, KRAS, CBL, FLT3, and janus kinase 2 (JAK2) genes, and hypermethylation of the promoter of the tumor suppressor gene TIF1γ, did not predict response or survival on DAC therapy.
|
21828134 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study suggests that TIF1gamma is critical for tumor suppression in the pancreas, brings new insight into the genetics of pancreatic cancer, and constitutes a promising model to decipher the respective roles of SMAD4 and TIF1gamma in the multifaceted functions of TGFbeta in carcinogenesis and development.
|
19629168 |
2009 |