|
Lupus Erythematosus, Systemic
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate how IFN responses in SLE keratinocytes contribute to development of CLE.
|
30745462 |
2019 |
|
Pancreatic Neoplasm
|
0.010 |
Biomarker
|
disease |
LHGDN |
Proteomic profiling in pancreatic cancer with and without lymph node metastasis.
|
19152423 |
2009 |
|
Panniculitis, Lupus Erythematosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The highest mean pruritus intensity was reported by subjects with hypertrophic LE (5.1 ± 3.0 points) followed by generalized discoid LE (3.6 ± 3.0 points), subacute CLE (3.0 ± 3.0 points), chilblain LE (3.0 ± 1.0 points), localized discoid LE (2.6 ± 2.0 points), intermittent CLE (2.6 ± 3.0 points), acute CLE (2.5 ± 1.2 points), and lupus erythematosus profundus (1.9 ± 2.7 points).
|
30148164 |
2018 |
|
Systemic Scleroderma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Some recent data have indicated that it may also be associated with autoimmune connective tissue diseases, including systemic sclerosis and dermatomyositis; however, studies on the prevalence and clinical characteristics of pruritus in CLE are limited.
|
30148164 |
2018 |
|
Niemann-Pick Disease, Type C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of chromosome 14 open reading frame 166 correlates with disease progression and poorer prognosis in human NPC.
|
25964093 |
2015 |
|
Adult type dermatomyositis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Some recent data have indicated that it may also be associated with autoimmune connective tissue diseases, including systemic sclerosis and dermatomyositis; however, studies on the prevalence and clinical characteristics of pruritus in CLE are limited.
|
30148164 |
2018 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multiple blinded raters validated CLE videos of lung tumours and mediastinal nodes twice.EUS-nCLE-FNA was performed in 22 patients with suspected or proven lung cancer in whom 27 lesions (six tumours, 21 mediastinal nodes) were evaluated without complications.
|
31023849 |
2019 |
|
Congenital emphysema
|
0.010 |
Biomarker
|
disease |
BEFREE |
The spacer sequence between the palindromic motifs is constant in length, but its sequence is highly variable among viral species, presenting a relaxed consensus (TT)GGKCCCY, which is similar to the Conserved Late Element or CLE (GTGGTCCC), a putative TrAP-responsive element.
|
30673741 |
2019 |
|
Intestinal metaplasia of gastric mucosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
CLE is useful for the detection of GIM, and luminal fluorescein leakage may represent a novel CLE marker for GIM.
|
28886101 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study indicates that the expression of C14orf166 is elevated in ESCC, and is potentially a valuable prognostic predictor for ESCC.
|
28000881 |
2017 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the expression and clinicopathological significance of C14ORF166 in cervical cancer.
|
26219895 |
2016 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multiple blinded raters validated CLE videos of lung tumours and mediastinal nodes twice.EUS-nCLE-FNA was performed in 22 patients with suspected or proven lung cancer in whom 27 lesions (six tumours, 21 mediastinal nodes) were evaluated without complications.
|
31023849 |
2019 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that C14orf166 promotes bladder cancer cell proliferation and can be a novel prognostic biomarker for patients with bladder cancer.
|
26905879 |
2016 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multiple blinded raters validated CLE videos of lung tumours and mediastinal nodes twice.EUS-nCLE-FNA was performed in 22 patients with suspected or proven lung cancer in whom 27 lesions (six tumours, 21 mediastinal nodes) were evaluated without complications.
|
31023849 |
2019 |
|
Childhood Ataxia with Central Nervous System Hypomyelinization
|
0.010 |
Biomarker
|
disease |
BEFREE |
The spacer sequence between the palindromic motifs is constant in length, but its sequence is highly variable among viral species, presenting a relaxed consensus (TT)GGKCCCY, which is similar to the Conserved Late Element or CLE (GTGGTCCC), a putative TrAP-responsive element.
|
30673741 |
2019 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The level of C14orf166 was correlated with serum alpha-fetoprotein level, lymph node metastasis, tumor size and recurrence, with high C14orf166 expression correlating with high HCC recurrence risk.
|
30907217 |
2019 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings reveal novel mechanisms by which polyphenolic extracts from ABE, LGE and especially CLE target the gut-liver axis to protect diet-induced obese mice against metabolic endotoxaemia, insulin resistance and hepatic steatosis, which importantly improves hepatic insulin clearance.
|
29270816 |
2018 |
|
Inflammatory dermatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which 70% of patients experience disfiguring skin inflammation (grouped under the rubric of cutaneous lupus erythematosus [CLE]).
|
30745462 |
2019 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the expression and clinicopathological significance of C14ORF166 in cervical cancer.
|
26219895 |
2016 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Importantly, delivery of the IL-6-receptor humanized monoclonal antibody tocilizumab robustly abrogates CGI-99-induced metastasis in vivo.
|
28166202 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
High expression of c14orf166 (cutoff score >6) was significantly associated with gender (P = 0.016), clinical stage (P = 0.010), T classification (P = 0.013), N classification (P = 0.029), distant metastasis (P < 0.001), vital status (P = 0.001), and treatment method (P = 0.028; chi-square test).
|
25964093 |
2015 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
LHGDN |
For the first time, c14orf166 was identified asa novel metastasis-associated protein, and the roles of radixin, moesin and c14orf166 in cancer metastasis deserve further investigations.
|
19152423 |
2009 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Taken together, we have isolated a novel protein CGI-99, which may be involved in the functional regulation of human ninein in the centrosome structure and may also be important in brain development and tumorigenesis.
|
15147888 |
2004 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
C14orf166, a 28 kD protein regulating RNA transcription and translation, may serve a critical role in oncogenesis.
|
28000881 |
2017 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Chromosome 14 ORF 166 (C14orf166), a protein involved in the regulation of RNA transcription and translation, has been reported to possess the potency to promote tumorigenesis; however, the role of C14orf166 in non-small-cell lung cancer (NSCLC) remains unknown.
|
30126850 |
2018 |