Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.030 Biomarker disease BEFREE Furthermore, DCA increased NDV replication in a PDK-1-dependent manner in HCC. 31819179 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.030 AlteredExpression disease BEFREE To the best of our knowledge, the present study is the first to identify the activation of PDK1 in HCC tissues, confirmed using western blot analysis. 29563998 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.030 AlteredExpression disease BEFREE Furthermore, we demonstrated that miR-105 could deactivated the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway by downregulating insulin receptor substrate-1, 3-phosphoinositide-dependent protein kinase-1 and AKT1 directly, resulting in increasing cyclin-dependent kinase inhibitors 1A and 1B (p21(Cip1) and p27(Kip1)) and decreasing cyclin D1 expression in HCC. 25280563 2014