Obesity
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Additionally, among the SNPs used for confirmation in both studies the AD risk allele of rs1858973, with an AD association just below genome-wide significance (pAD = 7.20 × 10(-07)), was also associated with obesity (SNP at IQCK/GPRC5B; pBMI = 5.21 × 10(-06) ; pcorr = 3.24 × 10(-04)).
|
24788522 |
2014 |
Obesity
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings suggest that GPRC5B may be a major node in adipose signaling systems linking diet-induced obesity to type 2 diabetes and may open new avenues for therapeutic approaches to diabetic progression.
|
23169819 |
2012 |
Obesity
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B.
|
20935630 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, pharmacological targeting of GPRC5B might provide a novel means therapy for the treatment and prevention of type-2 diabetes.
|
24404583 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings suggest that GPRC5B may be a major node in adipose signaling systems linking diet-induced obesity to type 2 diabetes and may open new avenues for therapeutic approaches to diabetic progression.
|
23169819 |
2012 |
Diabetic Nephropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We identified an orphan GPCR, Gprc5b, as a novel gene highly enriched in podocytes that was significantly upregulated in common human glomerulopathies, including diabetic nephropathy, IgA nephropathy, and lupus nephritis.
|
31285284 |
2019 |
Kidney Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Similar upregulation of Gprc5b was detected in LPS-induced nephropathy in mice.
|
31285284 |
2019 |
Lupus Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We identified an orphan GPCR, Gprc5b, as a novel gene highly enriched in podocytes that was significantly upregulated in common human glomerulopathies, including diabetic nephropathy, IgA nephropathy, and lupus nephritis.
|
31285284 |
2019 |
Myocarditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, our findings are the first to report a novel role of the orphan receptor GPRC5B in fibroblast-driven myocardial inflammation and cardiac remodeling.
|
31104767 |
2019 |
Renal glomerular disease
|
0.010 |
Biomarker
|
group |
BEFREE |
GPRC5b Modulates Inflammatory Response in Glomerular Diseases <i>via</i> NF-<i>κ</i>B Pathway.
|
31285284 |
2019 |
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Additionally, among the SNPs used for confirmation in both studies the AD risk allele of rs1858973, with an AD association just below genome-wide significance (pAD = 7.20 × 10(-07)), was also associated with obesity (SNP at IQCK/GPRC5B; pBMI = 5.21 × 10(-06) ; pcorr = 3.24 × 10(-04)).
|
24788522 |
2014 |
Impulsive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In the meta-analysis data, MAP2K5 was associated with inattention, GPRC5B with hyperactivity/impulsivity and inattention and CADM2 with hyperactivity/impulsivity.
|
23533005 |
2013 |
Inattention
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In the meta-analysis data, MAP2K5 was associated with inattention, GPRC5B with hyperactivity/impulsivity and inattention and CADM2 with hyperactivity/impulsivity.
|
23533005 |
2013 |
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In the meta-analysis data, MAP2K5 was associated with inattention, GPRC5B with hyperactivity/impulsivity and inattention and CADM2 with hyperactivity/impulsivity.
|
23533005 |
2013 |
Attention deficit hyperactivity disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
GPRC5B belongs to the metabotropic glutamate receptor family, which has been implicated in the etiology of ADHD.
|
23533005 |
2013 |
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice.
|
21840300 |
2011 |