SLC26A4, solute carrier family 26 member 4, 5172

N. diseases: 194; N. variants: 174
Disease: Asthma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE These findings collectively suggest that pendrin can induce mucus production in airway epithelial cells and may be a therapeutic target candidate for bronchial asthma and COPD. 18424749 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease LHGDN These findings collectively suggest that pendrin can induce mucus production in airway epithelial cells and may be a therapeutic target candidate for bronchial asthma and COPD. 18424749 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease LHGDN To determine whether pendrin might also play a role in virus-induced exacerbations of asthma, we measured pendrin mRNA expression in human subjects with naturally occurring common colds caused by rhinovirus and found a 4.9-fold increase in mean expression during colds. 18641360 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE To determine whether pendrin might also play a role in virus-induced exacerbations of asthma, we measured pendrin mRNA expression in human subjects with naturally occurring common colds caused by rhinovirus and found a 4.9-fold increase in mean expression during colds. 18641360 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease BEFREE There might be a protective effect of SLC26A4 mutations for asthma and hypertension but our study is statistically underpowered to detect this effect. 19289392 2009
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE However, the SLC26A4 hyperactivity was recently associated with the emergence of autoimmune thyroid diseases (AITD) and asthma among human and mouse model. 21045265 2010
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE Therefore, elucidating the transcriptional regulation of pendrin could aid in the development of new pharmacological leads for asthma and/or COPD therapy. 21814192 2011
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE Factors inducing an up-regulation of pendrin in the kidney and the lung may have an impact on the pathogenesis of hypertension, chronic obstructive pulmonary disease (COPD) and asthma. 22116359 2011
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE Additionally, pendrin up-regulation could play a role in the pathogenesis of several diseases including bronchial asthma and chronic obstructive pulmonary disease (COPD). 24429826 2013
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE Expression of Pendrin, an epithelial anion transporter, is increased in asthma and chronic obstructive pulmonary disease. 26143180 2015
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE Emerging data suggest that an increased expression of pendrin in airway epithelia is associated with elevated airway hyperreactivity in asthma. 28378089 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE We and others previously found pendrin/SLC26A4 as a downstream molecule of IL-13, a signature type 2 cytokine critical for asthma, and showed its significance in the pathogenesis of asthma using model mice. 29359006 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE Pendrin is a transmembrane chloride/anion antiporter that is strongly upregulated in the airways in rhinoviral infection, asthma, cystic fibrosis and chronic rhinosinusitis. 31281021 2019