Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
To determine whether pendrin might also play a role in virus-induced exacerbations of asthma, we measured pendrin mRNA expression in human subjects with naturally occurring common colds caused by rhinovirus and found a 4.9-fold increase in mean expression during colds.
|
18641360 |
2008 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings collectively suggest that pendrin can induce mucus production in airway epithelial cells and may be a therapeutic target candidate for bronchial asthma and COPD.
|
18424749 |
2008 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These findings collectively suggest that pendrin can induce mucus production in airway epithelial cells and may be a therapeutic target candidate for bronchial asthma and COPD.
|
18424749 |
2008 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether pendrin might also play a role in virus-induced exacerbations of asthma, we measured pendrin mRNA expression in human subjects with naturally occurring common colds caused by rhinovirus and found a 4.9-fold increase in mean expression during colds.
|
18641360 |
2008 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There might be a protective effect of SLC26A4 mutations for asthma and hypertension but our study is statistically underpowered to detect this effect.
|
19289392 |
2009 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the SLC26A4 hyperactivity was recently associated with the emergence of autoimmune thyroid diseases (AITD) and asthma among human and mouse model.
|
21045265 |
2010 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Factors inducing an up-regulation of pendrin in the kidney and the lung may have an impact on the pathogenesis of hypertension, chronic obstructive pulmonary disease (COPD) and asthma.
|
22116359 |
2011 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, elucidating the transcriptional regulation of pendrin could aid in the development of new pharmacological leads for asthma and/or COPD therapy.
|
21814192 |
2011 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Additionally, pendrin up-regulation could play a role in the pathogenesis of several diseases including bronchial asthma and chronic obstructive pulmonary disease (COPD).
|
24429826 |
2013 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of Pendrin, an epithelial anion transporter, is increased in asthma and chronic obstructive pulmonary disease.
|
26143180 |
2015 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Emerging data suggest that an increased expression of pendrin in airway epithelia is associated with elevated airway hyperreactivity in asthma.
|
28378089 |
2017 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We and others previously found pendrin/SLC26A4 as a downstream molecule of IL-13, a signature type 2 cytokine critical for asthma, and showed its significance in the pathogenesis of asthma using model mice.
|
29359006 |
2017 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pendrin is a transmembrane chloride/anion antiporter that is strongly upregulated in the airways in rhinoviral infection, asthma, cystic fibrosis and chronic rhinosinusitis.
|
31281021 |
2019 |