GHRL, ghrelin and obestatin prepropeptide, 51738

N. diseases: 183; N. variants: 11
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE Variation in the preproghrelin gene is not associated with juvenile-onset obesity, type 2 diabetes or related phenotypes among the examined Danish Caucasian subjects. 15820771 2005
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE The Leu72Met (+408C>A) polymorphism of the preproghrelin, has been linked to obesity, insulin resistance and diabetes. 22441120 2012
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE Mutations in the preproghrelin/ghrelin gene associated with obesity in humans. 11502844 2001
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE We examined 8 SNPs related to obesity: GHRL rs696217, PPARG rs1175544, ADIPOQ rs2241766, ADIPOQ rs1501299, PPARD rs2016520, APOA5 rs662799, BRAP rs3782886, and ITGB2 rs235326. 27245511 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. 16459454 2005
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE Minor homozygotes for five preproghrelin gene polymorphisms, namely, -1500C>G (rs3755777), -1062G>C (rs26311), -994C>T (rs26312) (promoter region), Leu72Met (rs696217) (exon 2), and +3056T>C (rs2075356) (intron 2), had high values of total and visceral fat areas, waist circumference, and BMI, indicating significant correlation of the polymorphisms with obesity and fat metabolism. 23257630 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE Therefore, the present study aimed to evaluate the relationships among the gene polymorphisms ghrelin (GHRL-rs26802), ghrelin receptor (GHSR-rs572169), leptin (LEP-rs7799039), leptin receptor (LEPR-rs1137101) and fat mass and obesity-associated (FTO-rs9939609) and obesity. 26255942 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE Relationships between obesity and common genomic variants of GHRL and GHS-R genes have been studied. 21345363 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE The Leu72Met (+408C>A) polymorphic variant of the preproghrelin, the gene for the ghrelin precursor, has been linked to obesity, diabetes and metabolic syndrome. 17884032 2008
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE Previous studies suggested that polymorphisms in the coding region of the preproghrelin were involved in the etiology of obesity and might modulate glucose-induced insulin secretion. 18071345 2008
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE Polymorphisms in preproghrelin and ghrelin gene could be responsible for obesity, insulin resistance and low ghrelin levels observed in some individuals. 19049992 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.500 GeneticVariation disease BEFREE To evaluate the association of A-604G SNP of GHRL promoter region with serum ghrelin levels and the risk of obesity in a Mexican population. 28597412 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease CTD_human
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease BEFREE The preproghrelin gene codes for two gut-derived circulating peptides that have been linked to anxiety-like behaviour in rodents: ghrelin (an orexigenic, pro-obesity hormone) and obestatin. 23084284 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease HPO
CUI: C0028754
Disease: Obesity
Obesity 		0.500 SusceptibilityMutation disease CLINVAR