GHRL, ghrelin and obestatin prepropeptide, 51738

N. diseases: 183; N. variants: 11
Disease: Obesity ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4684677
rs4684677
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		0.710 GeneticVariation BEFREE Replication of the nominal associations with obesity could not be confirmed in a German genome-wide association (GWA) study for rs4684677 and rs572169 polymorphisms. 19165163 2009
dbSNP: rs34911341
rs34911341
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		0.710 GeneticVariation BEFREE Arg51Gln mutation was associated with lower plasma ghrelin levels but not with obesity. 12181387 2002
dbSNP: rs34911341
rs34911341
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		T 0.710 SusceptibilityMutation CLINVAR
dbSNP: rs4684677
rs4684677
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		A 0.710 SusceptibilityMutation CLINVAR
dbSNP: rs696217
rs696217
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		0.050 GeneticVariation BEFREE Average dietary energy in lunch, rs3782886, and rs696217 were associated with obesity, and rs3782886 was associated with other metabolic abnormalities. 27245511 2019
dbSNP: rs696217
rs696217
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		0.050 GeneticVariation BEFREE Minor homozygotes for five preproghrelin gene polymorphisms, namely, -1500C>G (rs3755777), -1062G>C (rs26311), -994C>T (rs26312) (promoter region), Leu72Met (rs696217) (exon 2), and +3056T>C (rs2075356) (intron 2), had high values of total and visceral fat areas, waist circumference, and BMI, indicating significant correlation of the polymorphisms with obesity and fat metabolism. 23257630 2013
dbSNP: rs696217
rs696217
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		0.050 GeneticVariation BEFREE The Leu72Met (+408C>A) polymorphism of the preproghrelin, has been linked to obesity, insulin resistance and diabetes. 22441120 2012
dbSNP: rs696217
rs696217
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		0.050 GeneticVariation BEFREE The Leu72Met (+408C>A) polymorphic variant of the preproghrelin, the gene for the ghrelin precursor, has been linked to obesity, diabetes and metabolic syndrome. 17884032 2008
dbSNP: rs696217
rs696217
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		0.050 GeneticVariation BEFREE The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. 16459454 2005
dbSNP: rs26802
rs26802
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		0.010 GeneticVariation BEFREE Therefore, the present study aimed to evaluate the relationships among the gene polymorphisms ghrelin (GHRL-rs26802), ghrelin receptor (GHSR-rs572169), leptin (LEP-rs7799039), leptin receptor (LEPR-rs1137101) and fat mass and obesity-associated (FTO-rs9939609) and obesity. 26255942 2015
dbSNP: rs2075356
rs2075356
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		0.010 GeneticVariation BEFREE Minor homozygotes for five preproghrelin gene polymorphisms, namely, -1500C>G (rs3755777), -1062G>C (rs26311), -994C>T (rs26312) (promoter region), Leu72Met (rs696217) (exon 2), and +3056T>C (rs2075356) (intron 2), had high values of total and visceral fat areas, waist circumference, and BMI, indicating significant correlation of the polymorphisms with obesity and fat metabolism. 23257630 2013
dbSNP: rs26312
rs26312
Entrez Id: 51738;100126793
Gene Symbol: GHRL;GHRLOS
GHRL;GHRLOS
CUI: C0028754
Disease:
Obesity 		0.010 GeneticVariation BEFREE Minor homozygotes for five preproghrelin gene polymorphisms, namely, -1500C>G (rs3755777), -1062G>C (rs26311), -994C>T (rs26312) (promoter region), Leu72Met (rs696217) (exon 2), and +3056T>C (rs2075356) (intron 2), had high values of total and visceral fat areas, waist circumference, and BMI, indicating significant correlation of the polymorphisms with obesity and fat metabolism. 23257630 2013