WWOX, WW domain containing oxidoreductase, 51741

N. diseases: 356; N. variants: 58
Disease: Advanced breast cancer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3495917
Disease: Advanced breast cancer
Advanced breast cancer 		0.020 AlteredExpression disease BEFREE As a consequence progressive loss of WWOX expression in advanced breast cancer would contribute to the pro-metastatic effects resulting from TGFβ/SMAD3 hyperactive signaling in breast cancer. 24932569 2014
CUI: C3495917
Disease: Advanced breast cancer
Advanced breast cancer 		0.020 AlteredExpression disease BEFREE Since loss of WWOX expression increases with breast cancer progression and it behaves as an inhibitor of SMAD3 transcriptional activity these observations may help explain, at least in part, the paradoxical pro-tumorigenic effects of TGFβ signaling in advanced breast cancer. 24330518 2013