CDK12, cyclin dependent kinase 12, 51755

N. diseases: 54; N. variants: 25
Disease: Carcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 AlteredExpression phenotype BEFREE CDK12 overexpression promotes breast cancer tumorigenesis and maintains the stemness of breast cancer by activating c-myc/β-catenin signaling. 31744448 2020
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE Cyclin-dependent kinase 12 (CDK12) has emerged as an effective therapeutic target due to its ability to regulate DNA damage repair in human cancers, but little is known about the role of CDK12 in driving tumorigenesis. 31468695 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE We discuss the implications of our findings in light of recent reports linking cyclin K and CDK12 to human tumorigenesis. 29760377 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE In breast cancer cells, regulation by CDK12 modulates ALE splicing of the DNA damage response activator ATM and a DNAJB6 isoform that influences cell invasion and tumorigenesis in xenografts. 28334900 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE This review summarizes the role of CDK12 in transcription and RNA processing, in maintaining genomic stability/integrity and in tumorigenesis. 27662623 2016
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE Our finding provides new insight toward deciphering the function of CDK12 in genome maintenance and oncogenesis. 26787835 2016