CDK12, cyclin dependent kinase 12, 51755

N. diseases: 54; N. variants: 25
Disease: Malignant neoplasm of ovary ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 GeneticVariation disease BEFREE This genomic instability, denoted as the CDK12 TD-plus phenotype, is remarkably distinct from other alteration patterns described in breast and ovarian cancers. 26787835 2016
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 GeneticVariation disease BEFREE CDK12 mutations have been reported in many cancers and have been suggested as a cause of defective DNA repair in ovarian carcinoma. 27662623 2016
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 GeneticVariation disease BEFREE CDK12 is among only nine genes with recurrent somatic mutations in high-grade serous ovarian carcinoma. 25712099 2015
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.330 CausalMutation disease CGI