|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, circulating as well as tumor expression levels of PEDF have been inversely associated with tumor growth and metastasis.
|
30892156 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Pigment epithelium-derived factor (PEDF) is a secreted anticancer protein that can regulate lung cancer progression; however, the role of PEDF in non-small cell lung cancer (NSCLC), including metastasis and cancer cell-derived exosome secretion, is unclear.
|
30439539 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
PEDF demonstrated anti-proliferative and pro-apoptotic effects against human prostate and breast cancer cells, tumors which are known to metastasize to bone as the preferred secondary site.
|
31028961 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Correction: Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial-mesenchymal transition and metastasis.
|
30013023 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our findings indicate for the first time that PEDF functions as tumor-suppressor gene in the occurrence of EMT and metastasis in NPC.
|
28569772 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our results demonstrate a novel functional role of PEDF/LR axis in driving metastasis through ERK1/2-mediated EMT in HCC and provided a promising prognostic marker in HCC.
|
28771223 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Inhibiting TXNDC5 expression simultaneously led to the increased expression of SERPINF1 (serpin peptidase inhibitor, clade F) and TRAF1 (TNF receptor-associated factor 1), which have been reported to inhibit angiogenesis and metastasis as well as induce apoptosis.
|
29207620 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
MSCs engineered to secrete PEDF through adenoviral transduction significantly inhibited tumor metastasis and malignant ascites formation in CT26 CRPC mice.
|
26756933 |
2016 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
This review aims to summarize recent findings, the role of PEDF in cervical cancer treatment, and enhance the current understanding of the antitumor properties of PEDF such as inhibiting angiogenesis and metastasis, inducing tumor cell apoptosis and differentiation, and modulating cellular immunity against cervical cancer.
|
26122658 |
2015 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Metastases were reduced in PEDF-DTX-5 mg/kg compared with other treatments, suggesting that PEDF-DTX delayed metastases formation.
|
24810046 |
2014 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
OCM-1 cells expressing WT-PEDF, EEA-PEDF, or EEE-PEDF displayed significantly reduced tumor growth and metastasis in the melanoma xenograft of nude mice models, with the PEDF mutants displaying much stronger effects than the wild type.
|
22952124 |
2012 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis.
|
19661223 |
2010 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
In this study we report, for the first time, the multitargeted role of PEDF in the inhibition of growth, angiogenesis and metastasis of two orthotopic models of osteosarcoma (rat UMR 106-01 and human SaOS-2).
|
17479108 |
2007 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Among them, PAI-2 and DRHC were confirmed to be upregulated with real-time PCR and Western blot, suggesting a possible association with PEDF-induced signaling for cell motility and metastasis.
|
17471021 |
2007 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Angiostatin increases PEDF mRNA in melanoma metastases.
|
16735992 |
2006 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Moreover, the growth of PEDF-overexpressing pancreatic adenocarcinoma cells was significantly suppressed in comparison with control cells in peritoneal metastasis models.
|
16361561 |
2005 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
RGD |
In human cancer tissues, by immunohistochemistry and real-time quantitative reverse transcription-PCR, patients without metastases at diagnosis had higher tumor pigment epithelium-derived factor levels than tumors from patients with metastases at diagnosis.
|
15313905 |
2004 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
PEDF-mediated inhibition of melanoma metastases could thus have a major impact on existing therapies for melanoma.
|
15313901 |
2004 |