SERPINF1, serpin family F member 1, 5176

N. diseases: 294; N. variants: 15
Disease: Childhood Osteosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker disease BEFREE The question has been raised regarding the place of PEDF in the treatment of bone disorders and osteosarcoma, and its potential for tumour growth suppression. 29978595 2018
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker disease BEFREE We have recently shown that PEDF is one biological that has multiple anti-OS activity. 18487955 2008
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker disease BEFREE Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma. 17408737 2007
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker disease BEFREE Therefore, together these results suggest that PEDF may be a new and promising approach for the treatment of osteosarcoma. 17479108 2007
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker disease BEFREE Our present study provides novel beneficial aspects of PEDF on osteosarcoma cells; one is induction of apoptotic cell death of tumor cells, and the other is the suppression of VEGF expression, which would lead to inhibition of tumor angiogenesis. 15985268 2005