PER1, period circadian regulator 1, 5187

N. diseases: 111; N. variants: 8
Disease: Obsessive compulsive behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600104
Disease: Obsessive compulsive behavior
Obsessive compulsive behavior 		0.010 Biomarker disease BEFREE These data imply that chronic cortical/limbic GLU excitation of the STR desensitizes its co-excitatory d-serine & DA inputs while freezing its GABA output in an active state to mediate chronic tics and compulsions - possibly in part by abolishing striatal Per1-dependent ultradian extinction of urges and motions. 29481900 2018