Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
For patients who received combination therapy with medium/high doses of corticosteroids, the T-SPOT.TB positive rate (p = 0.046) and CFP-10 spot number (p = 0.041) were increased after treatment, with no significant changes in the total number of spots or ESAT-6 spots.
|
30917713 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
An electrochemical aptamer-based assay is described for the determination of CFP-10 which is an early secretary biomarker of Mycobacterium tuberculosis.
|
31473812 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of LAM and CFP-10 biomarkers in urinary EVs of TB patients by I-PCR showed superiority over ELISA.
|
31549171 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The current results indicate that PPD is a better antigen for antibody-based detection of TB than ESAT-6 and CFP-10.
|
31421107 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, as for IGRA assays such as Quantiferon and T-Spot TB tests, ESAT-6 and CFP-10 are unable to distinguish LTBI from active TB when IL-2 is measured.
|
29856871 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Highest diagnostic accuracies for active TB (AUC ≥ 0.91) were achieved for: (i) CD27 within IFN-γ<sup>+</sup>TNF-α<sup>+</sup>CD4<sup>+</sup> T-cells in response to ESAT-6/CFP-10, (ii) CD27 and CCR4 markers together within IFN-γ<sup>+</sup>CD4<sup>+</sup> T-cells in response to PPD, and (iii) CD27 MFI ratio performed on IFN-γ<sup>+</sup>TNF-α<sup>+</sup>CD4<sup>+</sup> T-cells after ESAT-6/CFP-10 stimulation.
|
30687314 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This method exhibits great application potential in the field of nanomedical science for highly reliable point-of-care detection of CFP-10 antigen in real samples to early diagnosis of tuberculosis.
|
30205244 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study confirms the high conservation for ESAT-6, CFP-10 and EspC in local M. bovis field isolates and reinforce the use of these three antigens in the diagnosis of bovine tuberculosis.
|
30029900 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Also, in this research, we proposed the incorporation of protein biomarker, Mycobacterium tuberculosis ESAT-6-like protein esxB (CFP-10), as a means of TB detection using plasmonic ELISA.
|
29899214 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we studied human pulmonary T-cell responses induced by the <i>M. tuberculosis</i>-specific antigen Rv3615c, a protein with a similar size and sequence homology to ESAT-6 and CFP-10, which induced dominant CD4<sup>+</sup> T-cell responses in human tuberculosis (TB) models.
|
28588103 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, we compared the levels of A antigen (ESAT-6) and B antigen (CFP-10) in active TB.
|
28345545 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of T Cells Specific for CFP-10 and ESAT-6 in Mycobacterium tuberculosis-Infected Mauritian Cynomolgus Macaques.
|
28115506 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CTL immunogenicity of Rv3615c antigen and diagnostic performances of an ESAT-6/CFP-10/Rv3615c antigen cocktail for Mycobacterium tuberculosis infection.
|
29050772 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that serum CFP-10 quantitation holds great promise for the rapid diagnosis of suspected TB cases in patients who are HIV-infected.
|
29089034 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although BfrB is not as immunodominant as ESAT-6/CFP-10 during acute M.tb infection, comparable BfrB-specific cellular immune responses are observed in LTBI population with the potential to increase the sensitivity for LTBI screening.
|
29050758 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These 2 antigens are good targets for tuberculosis (TB) detection.To rapidly diagnose TB across a variety of samples, we developed colloidal gold immunochromatographic strips (ICSs) based on ESAT-6 and CFP-10.The strips were evaluated using 233 samples, including sputum, plasma, and pleural effusion samples.The positive detection rates for ICSs for ESAT-6 and CFP-10 in sputum (culture-positive for M tuberculosis) were 100% and 91.2%, respectively.
|
29390519 |
2017 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In patients with positive ELISpot in pleural fluid (n = 16), the PPV for TB was 85.7%, which increased to 91.7% for the ESAT-6 panel and 92.3% for the CFP-10 panel after the introduction of a cut-off >1.0 for the ratio between the pleural fluid and blood interferon-gamma responses.
|
28024452 |
2017 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multicolor flow cytometry analysis of whole-blood cultures showed higher Lpd-specific Th1 recall response (IFN-γ, TNF-α, and IL-2; <i>P</i> = 0.0006) and memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells (CCR7<sup>+</sup> CD45RA<sup>-</sup> and CCR7<sup>-</sup> CD45RA<sup>-</sup>) in healthy household contacts (HHC) of TB (<i>P</i> < 0.0001), which is comparable with or higher than the standard antigens, ESAT-6 and CFP-10.
|
28428201 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings from a study of naturally infected human population suggest that IFN-γ, TNF-α and IL-10 against rESAT-6/CFP-10 are markers for clinical TB but not for protective immunity.
|
28374535 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, immunogenicity of a fusion protein which consisting or comprising CFP-10 from Mycobacterium tuberculosis and the Fc-domain of mouse IgG2a was evaluated as a novel subunit vaccine candidate against TB.
|
28293387 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Replacing Trp(55) (W55) or Gly(57) (G57) residues in the putative W-X-G motif of EspA with arginines impaired ESAT-6 and CFP-10 secretion in vitro and attenuated M. tuberculosis.
|
24078612 |
2013 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The sensitivity of the IgG test ranged from 69.4% (ESAT-6) to 77.6% (ESAT-6/14KD/38KD) in the active TB patients; the specificity of assays varied from 78.4% (CFP-10) to 90.2% (14KD+38KD) in the healthy control groups.
|
23338746 |
2013 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Limited T cell receptor beta variable repertoire responses to ESAT-6 and CFP-10 in subjects infected with Mycobacterium tuberculosis.
|
23845455 |
2013 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrated that significantly higher levels of polyfunctional CD4(+) T cells for the epitopes of ESAT-6 or CFP-10 in PFCs may play an important role in the local control of tuberculosis (TB) infection.
|
22154006 |
2012 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to identify immunodominant antigens of Mycobacterium tuberculosis that may be used in the serodiagnosis of active tuberculosis (TB), we designed an M. tuberculosis fusion protein consisting of CFP-10 (10-kDa culture filtrate protein), ESAT-6 (6-kDa early secreted antigenic target), and the extracellular domain fragment of PPE68 (PPE68').
|
22357648 |
2012 |