|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Genetic variants of red-cell acid phosphatase (ACP1), esterase D (ESD), transferrin (TF) and the group-specific component (GC) were investigated in schizophrenic patients with and without a family history of both schizophrenia and other psychiatric disorders.
|
2365372 |
1990 |
|
Acrokeratoelastoidosis of Costa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loose linkage is possible between AKE and ACP1, IGKC, and Jk, but the estimated recombination fractions do not reach significant deviations from 0.5.
|
6221990 |
1983 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Protein tyrosine phosphatase (PTPase) activity was examined in two cell lines: human umbilical vein endothelial (HUVE) cells, which display contact inhibition of cell growth, and A427 human adenocarcinoma cells, which have lost this ability.
|
7575486 |
1995 |
|
Adult Brain Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we further evaluated the antitumor efficacy of an ACP1 sulphated derivative (ACP1‑s) in the human brain glioblastoma U87MG cell line.
|
29286151 |
2018 |
|
Adult Craniopharyngioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In order to develop robust in vivo drug testing methodology, the murine orthotopic craniopharyngioma model (PDX) was characterized by magnetic resonance imaging (MRI) and histology in xenografts from three patients (ACP1-3).
|
29795641 |
2018 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest the potential value of ACP1‑s as a novel therapeutic agent for the treatment of glioblastoma.
|
29286151 |
2018 |
|
Aniridia
|
0.030 |
Biomarker
|
disease |
BEFREE |
The presence of an autosomal dominant aniridia gene linked to acid phosphatase-1 on chromosome arm 2p and the existence of an aniridia syndrome resulting from deletion of band 13 of the short arm of chromosome 11 establishes a chromosome basis for genetic heterogeneity of aniridia phenotypes.
|
6929510 |
1980 |
|
Aniridia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Linkage analysis between the aniridia phenotype and ACP1 does not support the original linkage results, excluding linkage up to theta = 0.17 with Z = -2.
|
1505982 |
1992 |
|
Aniridia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We have excluded linkage (zeta less than -2 at theta less than 0.18) between the aniridia and the chromosome 2p25 marker D2S1 (linked to ACP1).
|
2575483 |
1989 |
|
Aniridia type 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this report, the kindred segregating for autosomal dominant aniridia, which suggested linkage to acid phosphatase-1 (ACP1) and led to the assignment of the AN1 locus on chromosome 2p, has been updated and expanded.
|
1505982 |
1992 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since ACP1 has been found to be associated with immunological diseases, our observation reinforces the notion of an immune component in the pathogenesis of atherosclerosis.
|
19246900 |
2009 |
|
Asthma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The analysis of pairwise gametic type distribution for ACP1, ADA and MN polymorphisms has shown that the pattern of differences between bronchial asthma and controls is opposite to that observed between CD and controls.
|
16224193 |
2005 |
|
Asthma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Notably, genetic interaction between <i>RhoA</i> and <i>SHP2</i> indicated that RhoA inactivation and <i>SHP2</i> deletion synergistically attenuated the allergen-induced eosinophil infiltration into lungs and airway hyperreactivity, whereas overexpression of active RhoA robustly restored the <i>SHP2</i> deletion-resultant attenuation of allergen-induced eosinophil recruitment into lungs and airway hyperreactivity as well.
|
31361966 |
2019 |
|
Asthma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms of protein-tyrosine phosphatase receptor-type delta gene and its association with pediatric asthma in the Taiwanese population.
|
18414509 |
2008 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since ACP1 has been found to be associated with immunological diseases, our observation reinforces the notion of an immune component in the pathogenesis of atherosclerosis.
|
19246900 |
2009 |
|
Autistic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated several single nucleotide polymorphisms (SNPs) of Forkhead Box P2 (FOXP2) and Protein-Tyrosine Phosphatase, Receptor-type, Zeta-1 (PTPRZ1) at the 7q region in Japanese patients with autism and healthy controls.
|
15998549 |
2005 |
|
Autoimmune Diseases
|
0.040 |
GeneticVariation
|
group |
BEFREE |
The red cell acid phosphatease (ACP1) gene, which encodes a low molecular weight phosphotyrosine phosphatase (LMW-PTP), has been suggested as a common genetic factor of autoimmunity.
|
22428720 |
2012 |
|
Autoimmune Diseases
|
0.040 |
GeneticVariation
|
group |
BEFREE |
The red cell acid phosphatase (ACP1) gene, which encodes a low-molecular-weight phosphotyrosine phosphatase, has been suggested as a common genetic factor of autoimmunity.
|
22064183 |
2012 |
|
Autoimmune Diseases
|
0.040 |
GeneticVariation
|
group |
BEFREE |
The R620W polymorphism in the protein-tyrosine-phosphatase nonreceptor type 22 gene (PTPN22) confers susceptibility to type 1 diabetes (T1D) and other autoimmune diseases.
|
20510318 |
2010 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
In view of the current interest in gender differences in autoimmune diseases we reviewed our data to enlighten possible effects of gender on the relationship between ACP1 and class of immunological disease.
|
17284925 |
2007 |
|
Bipolar Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
After controlling for genetic architecture and gender, we replicated rs300774 (p = 0.012), near ACP1 (acid phosphatase 1), the top predictor of suicide attempts in the BD study.The result of Willour et al.
|
28668716 |
2017 |
|
Blood Group Incompatibility
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Women with high-ADA activity and low-ACP1 activity, on the contrary, show the highest susceptibility to RSA and also the highest incidence of auto antibodies and of A blood group incompatibility.
|
17565542 |
2007 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Brain Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we further evaluated the antitumor efficacy of an ACP1 sulphated derivative (ACP1‑s) in the human brain glioblastoma U87MG cell line.
|
29286151 |
2018 |