ACP1, acid phosphatase 1, 52

N. diseases: 107; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 GeneticVariation disease BEFREE A maximum lod score of +1.01 (at theta = 0.001) between ACP1 and a breast cancer susceptibility locus was seen in the asynchronous all-cases subsample. 2766568 1989
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE Significant differences were observed in the phosphorylation level of PTPα at Tyr789 between the FAK‑Del33 and the wild‑type breast cancer cells, suggesting that FAK regulated the phosphorylation level of PTPα at Tyr789 in breast cancer mutant FAK‑Del33 cells. 25625869 2015
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.010 Biomarker disease BEFREE Implication of a protein-tyrosine-phosphatase in human lung cancer. 7981622 1994
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.010 GeneticVariation group BEFREE Likewise, the ACP1*C allele showed evidence of association with CV events in patients with RA (P = 0.024, OR = 2.43). 21767392 2011
CUI: C4554065
Disease: Childhood Brain Glioblastoma
Childhood Brain Glioblastoma 		0.010 Biomarker disease BEFREE In the present study, we further evaluated the antitumor efficacy of an ACP1 sulphated derivative (ACP1‑s) in the human brain glioblastoma U87MG cell line. 29286151 2018
CUI: C0278652
Disease: Childhood Craniopharyngioma
Childhood Craniopharyngioma 		0.010 GeneticVariation disease BEFREE In order to develop robust in vivo drug testing methodology, the murine orthotopic craniopharyngioma model (PDX) was characterized by magnetic resonance imaging (MRI) and histology in xenografts from three patients (ACP1-3). 29795641 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.010 Biomarker disease BEFREE These findings suggest the potential value of ACP1‑s as a novel therapeutic agent for the treatment of glioblastoma. 29286151 2018
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 AlteredExpression disease BEFREE In this report, we demonstrate that cellular protein tyrosine phosphatase (PTPase) activity (especially in cytosol) in monoblastoid leukemia U937 cells increased up to 2-fold during the course of monocytic differentiation. 8117617 1993
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.010 Biomarker disease BEFREE Interestingly, none of the aCGH diploid CLL cases showed gain of ACP1. 22035742 2011
CUI: C0009319
Disease: Colitis
Colitis 		0.010 GeneticVariation disease BEFREE Moreover, subcellular localization of the ezrin phosphomimetic Y353E or Y145 mutants were disrupted in colonic Caco-2 cells, similar to ezrin mislocalization in the colon of PTPσ(-/-) mice following induction of colitis. 24385580 2014
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.020 AlteredExpression group LHGDN Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers. 16036221 2005
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.020 GeneticVariation group LHGDN ACP1 genetic polymorphism and colon cancer. 18786445 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.010 GeneticVariation group BEFREE Protein-tyrosine phosphatase-L1 (PTPL1, also known as FAP-1, PTP1E, PTP-BAS, and PTPN13) is mutated in a significant number of colorectal tumors and may play a role in down-regulating signaling responses mediated by phosphatidylinositol 3-kinase, although the precise substrates are as yet unknown. 15611135 2005
CUI: C0852733
Disease: Completed Suicide
Completed Suicide 		0.010 GeneticVariation phenotype BEFREE The associated SNPs on 2p25 fall in a large linkage disequilibrium block containing the ACP1 (acid phosphatase 1) gene, a gene whose expression is significantly elevated in BP subjects who have completed suicide. 21423239 2012
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality 		0.010 GeneticVariation group BEFREE The Cardiff survey did show a significant relationship between ACP-1 genotypes and the presence or absence of congenital abnormalities, but since this was largely attributable to an excess of ACP-1 CA individuals with abnormalities, a category with a small expected value, further data are required to confirm the validity of this observation. 3208680 1989
CUI: C0009691
Disease: Congenital cataract
Congenital cataract 		0.010 GeneticVariation disease BEFREE Yeast two-hybrid analysis showed stronger interaction between the total CC-associated mutant EPHA2 and low molecular weight protein-tyrosine phosphatase, a negative regulator of EPHA2 signaling. 19306328 2009
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease 		0.010 GeneticVariation group BEFREE Besides several common chromosomal aberrations associated with 2p gain, we demonstrated a novel observation that gain of the telomeric region 2p25.3 harboring the ACP1 gene is common in CLL (25%, 44 of 178 cases). 22035742 2011
CUI: C0234972
Disease: Convulsive disorder
Convulsive disorder 		0.010 Biomarker disease BEFREE This is not observed in carriers of other ACP1 types.The present data suggest an epistatic action of ACP1 concerning the effect of Hp on the susceptibility to convulsive disorders. 19569003 2008
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.010 GeneticVariation disease BEFREE ACP1 genetic polymorphism and coronary artery disease: an association study. 19246900 2009
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.030 GeneticVariation disease BEFREE The rs3828329 of ACP1 gene is also a risk factor of CAD in Han Chinese females aged 65 years and older. 25123136 2014
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.030 Biomarker disease BEFREE The fact that the association of ACP1 with CAD is evident only in diabetic subjects, whereas the association of ADA1 with CAD is evident only in nondiabetic subjects suggests an heterogeneity in the pathogenetic mechanisms leading to CAD. 20581655 2010
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.030 Biomarker disease BEFREE ACP1 may be involved in susceptibility to CAD. 19246900 2009
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.010 GeneticVariation disease BEFREE ACP1 genetic polymorphism and coronary artery disease: an association study. 19246900 2009
CUI: C0010276
Disease: Craniopharyngioma
Craniopharyngioma 		0.010 GeneticVariation disease BEFREE In order to develop robust in vivo drug testing methodology, the murine orthotopic craniopharyngioma model (PDX) was characterized by magnetic resonance imaging (MRI) and histology in xenografts from three patients (ACP1-3). 29795641 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.030 Biomarker disease BEFREE The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 22 females) and 358 consecutive newborns (194 males and 164 females). cLMWPTP phenotypes showing a high concentration of F isoforms are associated with CD in females and with UC in males. 11381200 2000