ACP1, acid phosphatase 1, 52

N. diseases: 107; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.030 GeneticVariation disease BEFREE The polymorphisms of protein-tyrosine phosphatase receptor-type delta gene and its association with pediatric asthma in the Taiwanese population. 18414509 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.030 GeneticVariation disease BEFREE After the analysis, no evidence of association of the ACP1 genetic variants was found with CD or UC. 22428720 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.030 GeneticVariation disease BEFREE After the analysis, no evidence of association of the ACP1 genetic variants was found with CD or UC. 22428720 2012
CUI: C0011847
Disease: Diabetes
Diabetes 		0.030 GeneticVariation disease BEFREE Univariate analysis showed that the cumulative risk of development of diabetes within 5 years varied according to age, relationship to the proband, positivity for IAA, IA-2A and GADA, number and combination of islet antibodies, HLA class II genotype, baseline glucose tolerance, and first-phase insulin secretion, but not gender or incidence of childhood type 1 diabetes in the background population. 16514546 2006
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.030 GeneticVariation disease BEFREE The rs3828329 of ACP1 gene is also a risk factor of CAD in Han Chinese females aged 65 years and older. 25123136 2014
CUI: C0000786
Disease: Spontaneous abortion
Spontaneous abortion 		0.020 GeneticVariation phenotype LHGDN The data are in agreement with those expected on the basis of the effects of ACP1 and ADA genetic variability on T-cell receptor activity and suggest a cooperative effect of the two polymorphic systems in the susceptibility/resistance to repeated spontaneous abortion. 17565542 2007
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 GeneticVariation disease BEFREE A maximum lod score of +1.01 (at theta = 0.001) between ACP1 and a breast cancer susceptibility locus was seen in the asynchronous all-cases subsample. 2766568 1989
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.020 GeneticVariation group LHGDN ACP1 genetic polymorphism and colon cancer. 18786445 2008
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.020 GeneticVariation disease BEFREE PTPN22 and ACP1 show an additive effect with p53 codon 72 concerning their effect on endometriosis. 26216523 2016
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.020 GeneticVariation disease BEFREE These findings suggest that carriers of high activity ACP1 genotypes are more susceptible to endometriosis but less susceptible to allergic manifestations than carriers of other ACP1 genotypes. 18490013 2008
CUI: C0015702
Disease: Favism
Favism 		0.020 GeneticVariation disease BEFREE Association between ACP(1) genetic polymorphism and favism. 21644204 2011
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.020 GeneticVariation group BEFREE In NIDDM subjects we have found that ACP1 genotype is a highly significant predictor of retinopathy, suggesting that genetic variability of signal transduction may have an important role in the susceptibility to this complication. 9405929 1997
CUI: C0040517
Disease: Gilles de la Tourette syndrome
Gilles de la Tourette syndrome 		0.020 GeneticVariation disease BEFREE In the present study we examined the ACP1*A SNP in 539 screened controls and 184 male Tourette syndrome (TS) cases, all Caucasians of European descent. 12231445 2002
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.020 GeneticVariation phenotype BEFREE We tested whether variation in ACP1 is associated with type 2 diabetes-related traits in 1035 individuals in 339 Mexican-American families of probands with or without a previous diagnosis of gestational diabetes mellitus (GDM). 19622628 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 GeneticVariation disease BEFREE A maximum lod score of +1.01 (at theta = 0.001) between ACP1 and a breast cancer susceptibility locus was seen in the asynchronous all-cases subsample. 2766568 1989
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality 		0.010 GeneticVariation group BEFREE The Cardiff survey did show a significant relationship between ACP-1 genotypes and the presence or absence of congenital abnormalities, but since this was largely attributable to an excess of ACP-1 CA individuals with abnormalities, a category with a small expected value, further data are required to confirm the validity of this observation. 3208680 1989
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 GeneticVariation disease BEFREE Likewise, the ACP1*C allele showed evidence of association with CV events in patients with RA (P = 0.024, OR = 2.43). 21767392 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.010 GeneticVariation disease BEFREE We investigated several single nucleotide polymorphisms (SNPs) of Forkhead Box P2 (FOXP2) and Protein-Tyrosine Phosphatase, Receptor-type, Zeta-1 (PTPRZ1) at the 7q region in Japanese patients with autism and healthy controls. 15998549 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.010 GeneticVariation disease BEFREE After controlling for genetic architecture and gender, we replicated rs300774 (p = 0.012), near ACP1 (acid phosphatase 1), the top predictor of suicide attempts in the BD study.The result of Willour et al. 28668716 2017
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.010 GeneticVariation group BEFREE Likewise, the ACP1*C allele showed evidence of association with CV events in patients with RA (P = 0.024, OR = 2.43). 21767392 2011
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease 		0.010 GeneticVariation group BEFREE Besides several common chromosomal aberrations associated with 2p gain, we demonstrated a novel observation that gain of the telomeric region 2p25.3 harboring the ACP1 gene is common in CLL (25%, 44 of 178 cases). 22035742 2011
CUI: C0009319
Disease: Colitis
Colitis 		0.010 GeneticVariation disease BEFREE Moreover, subcellular localization of the ezrin phosphomimetic Y353E or Y145 mutants were disrupted in colonic Caco-2 cells, similar to ezrin mislocalization in the colon of PTPσ(-/-) mice following induction of colitis. 24385580 2014
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.010 GeneticVariation group BEFREE Protein-tyrosine phosphatase-L1 (PTPL1, also known as FAP-1, PTP1E, PTP-BAS, and PTPN13) is mutated in a significant number of colorectal tumors and may play a role in down-regulating signaling responses mediated by phosphatidylinositol 3-kinase, although the precise substrates are as yet unknown. 15611135 2005
CUI: C0009691
Disease: Congenital cataract
Congenital cataract 		0.010 GeneticVariation disease BEFREE Yeast two-hybrid analysis showed stronger interaction between the total CC-associated mutant EPHA2 and low molecular weight protein-tyrosine phosphatase, a negative regulator of EPHA2 signaling. 19306328 2009
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.010 GeneticVariation disease BEFREE ACP1 genetic polymorphism and coronary artery disease: an association study. 19246900 2009