|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Corresponding to increased progesterone receptor gene expression, the proliferation-associated antigen Ki-67 was also significantly elevated in the leiomyoma tissue.
|
8333481 |
1993 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that (1) ER binding was twice and PR binding was three times as great in fibroid as in myometrium and that there was no difference in binding for either receptor between fibroids from untreated and GnRHa pretreated women, (2) ER and PR mRNA abundances were similar in fibroids and myometrium from untreated women and in fibroids from untreated and GnRHa pretreated women, and (3) ER binding and ER mRNA abundance in both groups of fibroids and myometrium were independent of each other, but there was a positive correlation between PR binding and PR mRNA abundance in untreated fibroids and myometrium but not in GnRHa pretreated tumours.
|
8187322 |
1994 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We propose that increased expression of progesterone receptor in leiomyoma is most likely a consequence of overexpression of functional ER that results in increased end-organ sensitivity to estradiol.
|
7775635 |
1995 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast to the reduced transcript levels observed for the immediate early genes, the ER and PR mRNA contents of the leiomyomas and myometrium did not differ.
|
9253340 |
1997 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis of cells for estrogen receptor-alpha and progesterone receptor proteins by Western blotting showed no change in expression of these proteins between the immortalized and parental leiomyoma and myometrial cells.
|
12065682 |
2002 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The amount of cells positively stained for PR-AB and PR-B in fibroids and myometrium decreased after GnRH-a treatment compared with in the proliferative phase.
|
12413982 |
2002 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells.
|
15572421 |
2005 |
|
Fibroid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed no significant difference of the PGR*T1/T2 genotypes and allele frequencies between leiomyoma and other two groups.
|
15807882 |
2005 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
LHGDN |
Estrogen and progesterone receptors expression in gastrointestinal stromal tumors and intramural gastrointestinal leiomyomas.
|
17992477 |
2006 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, progesterone via PR interacts with the bcl-2 promoter to induce its expression in leiomyoma tissue.
|
17785366 |
2007 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The mean average results showed that ERbeta was 2.5-fold statistically significantly over expressed in postmenopausal leiomyomas compared to patient matched myometrium (p=0.038), whereas ERalpha and PGR were not significantly differently expressed.
|
17646097 |
2007 |
|
Fibroid Tumor
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The progesterone receptor gene polymorphism, PROGINS, may be a factor related to the development of uterine fibroids.
|
17224149 |
2007 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Taken together, progesterone via PR interacts with the bcl-2 promoter to induce its expression in leiomyoma tissue.
|
17785366 |
2007 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The selective progesterone receptor modulator asoprisnil suppresses uterine bleeding and decreases leiomyoma volume while maintaining follicular phase estrogen concentrations.
|
19176543 |
2009 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present study was conducted to elucidate whether progesterone affects IGF-I mRNA through progesterone receptor B(PRB) mRNA in leiomyoma.
|
19499404 |
2009 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Leiomyoma progesterone receptor mRNA levels were significantly higher in Japanese women compared with African-American or Caucasian-American women.
|
19240151 |
2009 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrated previously that LAT2 is a progesterone receptor target gene involved in leiomyoma growth.
|
20601542 |
2010 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RU486 stimulated recruitment of Sp1, RNA polymerase II, PR, and the coactivators SRC-1 and SRC-2 to the distal region and basal promoter. siRNA knockdown of PR increased KLF11 expression, whereas knockdown of KLF11 increased leiomyoma cell proliferation and abolished the antiproliferative effect of RU486.
|
20124487 |
2010 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies testing various selective progesterone receptor modulators for the treatment of leiomyomas are also highlighted.
|
21672608 |
2012 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To assess gene and protein expression of progesterone receptor isoforms A and B, cell cycle regulators p53 and p21 in leiomyoma and myometrium.
|
22350293 |
2012 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Progesterone receptor modulators, such as mifepristone are useful and well tolerated in reducing leiomyoma volume although with large individual variation.
|
24324590 |
2013 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Protein levels of PR-M, PR-B, PR-A, mitochondrial porin, and glyceraldehyde-3-phosphate dehydrogenase were determined in the myometrium and adjacent edge of a fibroid in 10 subjects undergoing hysterectomy for benign indications.
|
24423317 |
2014 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our analyses identified secreted Frizzled-related protein 4 (sFRP4) as a key gene product functionally linked to PR activation whose expression was 2.6 times higher in leiomyomas than myometrium (n = 26, P < 0.01) and 2.5 times higher during the proliferative phase of the menstrual cycle (n = 26, P < 0.01).
|
28637297 |
2017 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transthoracic needle biopsy was performed and the resected lesion consisted of benign spindle cells was positive for estrogen receptor (ER) and progesterone receptor (PR) and was diffuse positive for actin and desmin by immunohistochemical (IHC) staining, suggesting leiomyoma.
|
28203428 |
2017 |
|
Fibroid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MEDLINE using PubMed, Science Direct, and Google Scholar databases was searched using the terms "PROGINS," "progesterone receptor," "polymorphism," and "leiomyoma."
|
29630404 |
2018 |