|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, perilipin-2 (PLIN2) was identified as a critical target gene of the progesterone receptor; however, its function in the pathogenesis of fibroids is unknown.
|
31504629 |
2019 |
|
Fibroid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to analyze the effect of ERα-351 XbaI A/G, ERα-397 PvuII T/C, and progesterone receptor (PGR) PROGINS polymorphisms on the development of leiomyomas.
|
30390345 |
2019 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The selective progesterone receptor modulator, ulipristal acetate, has been reported to decrease the size of leiomyomas in clinical trials.
|
30567472 |
2019 |
|
Fibroid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MEDLINE using PubMed, Science Direct, and Google Scholar databases was searched using the terms "PROGINS," "progesterone receptor," "polymorphism," and "leiomyoma."
|
29630404 |
2018 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To evaluate progesterone receptor (PR), epithelial growth factor receptor (EGF-R), and galectin-3 expression in LMs, ALMs, STUMPs, and leiomyosarcomas and to assess their possible role in differentiating those tumors.
|
29729689 |
2018 |
|
Fibroid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conversely, the highest RANKL levels were found in the PR-rich leiomyoma intermediate cell (LIC) population.
|
29741640 |
2018 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our analyses identified secreted Frizzled-related protein 4 (sFRP4) as a key gene product functionally linked to PR activation whose expression was 2.6 times higher in leiomyomas than myometrium (n = 26, P < 0.01) and 2.5 times higher during the proliferative phase of the menstrual cycle (n = 26, P < 0.01).
|
28637297 |
2017 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transthoracic needle biopsy was performed and the resected lesion consisted of benign spindle cells was positive for estrogen receptor (ER) and progesterone receptor (PR) and was diffuse positive for actin and desmin by immunohistochemical (IHC) staining, suggesting leiomyoma.
|
28203428 |
2017 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Protein levels of PR-M, PR-B, PR-A, mitochondrial porin, and glyceraldehyde-3-phosphate dehydrogenase were determined in the myometrium and adjacent edge of a fibroid in 10 subjects undergoing hysterectomy for benign indications.
|
24423317 |
2014 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Progesterone receptor modulators, such as mifepristone are useful and well tolerated in reducing leiomyoma volume although with large individual variation.
|
24324590 |
2013 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies testing various selective progesterone receptor modulators for the treatment of leiomyomas are also highlighted.
|
21672608 |
2012 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To assess gene and protein expression of progesterone receptor isoforms A and B, cell cycle regulators p53 and p21 in leiomyoma and myometrium.
|
22350293 |
2012 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrated previously that LAT2 is a progesterone receptor target gene involved in leiomyoma growth.
|
20601542 |
2010 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RU486 stimulated recruitment of Sp1, RNA polymerase II, PR, and the coactivators SRC-1 and SRC-2 to the distal region and basal promoter. siRNA knockdown of PR increased KLF11 expression, whereas knockdown of KLF11 increased leiomyoma cell proliferation and abolished the antiproliferative effect of RU486.
|
20124487 |
2010 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The selective progesterone receptor modulator asoprisnil suppresses uterine bleeding and decreases leiomyoma volume while maintaining follicular phase estrogen concentrations.
|
19176543 |
2009 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present study was conducted to elucidate whether progesterone affects IGF-I mRNA through progesterone receptor B(PRB) mRNA in leiomyoma.
|
19499404 |
2009 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Leiomyoma progesterone receptor mRNA levels were significantly higher in Japanese women compared with African-American or Caucasian-American women.
|
19240151 |
2009 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, progesterone via PR interacts with the bcl-2 promoter to induce its expression in leiomyoma tissue.
|
17785366 |
2007 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The mean average results showed that ERbeta was 2.5-fold statistically significantly over expressed in postmenopausal leiomyomas compared to patient matched myometrium (p=0.038), whereas ERalpha and PGR were not significantly differently expressed.
|
17646097 |
2007 |
|
Fibroid Tumor
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The progesterone receptor gene polymorphism, PROGINS, may be a factor related to the development of uterine fibroids.
|
17224149 |
2007 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Taken together, progesterone via PR interacts with the bcl-2 promoter to induce its expression in leiomyoma tissue.
|
17785366 |
2007 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
LHGDN |
Estrogen and progesterone receptors expression in gastrointestinal stromal tumors and intramural gastrointestinal leiomyomas.
|
17992477 |
2006 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells.
|
15572421 |
2005 |
|
Fibroid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed no significant difference of the PGR*T1/T2 genotypes and allele frequencies between leiomyoma and other two groups.
|
15807882 |
2005 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis of cells for estrogen receptor-alpha and progesterone receptor proteins by Western blotting showed no change in expression of these proteins between the immortalized and parental leiomyoma and myometrial cells.
|
12065682 |
2002 |