|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Defective CpG methylation affecting several genes that encode key transcription factors such as GATA6, steroidogenic factor-1, and estrogen receptor-β in endometriosis gives rise to overproduction of local estrogen and prostaglandins and suppression of progesterone receptor.
|
26036904 |
2015 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients with endometriosis (n = 150) and fertile controls (n = 199) were genotyped for polymorphisms in oestrogen receptor genes ESR1 (rs2234693 - T/C single nucleotide polymorphism (SNP), dinucleotide (TA)(n) repeat) and ESR2 (dinucleotide (CA)(n) repeat), progesterone receptor gene PGR (rs10895068 - G/A SNP, 306-bp Alu-insertion), 17β-hydroxysteroid dehydrogenase type 1 gene HSD17B1 (rs605059 - A/G SNP), and aromatase gene CYP19A1 (rs10046 - C/T SNP, (TTTA)(n) tetranucleotide repeat, 3-bp TCT insertion/deletion polymorphism).
|
20586553 |
2011 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Dienogest (DNG), a selective progesterone receptor agonist, is widely used to treat endometriosis and efficiently relieves the symptoms.
|
25767055 |
2015 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
An immunohistochemistry study demonstrated that the estrogen receptor (ER) and progesterone receptor (PR) were positive in the endometriosis part but negative in the cancer part, while the human EGF receptor (HER) 2 was negative or very weak in the benign part and positive in the malignant part in all three cases.
|
29998468 |
2018 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased AKT or MEK1/2 activity influences progesterone receptor levels and localization in endometriosis.
|
24064688 |
2013 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Progesterone receptor (PR) modulators are used in contraception and post-menopausal hormone therapy, and are under clinical development for reproductive disorders such as uterine fibroids and endometriosis.
|
19013437 |
2009 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggest that the CRISPLD2 is a target of the progesterone receptor and may play an important role in pathogenesis of endometriosis.
|
24955763 |
2014 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Efficacy, safety and recurrence of new progestins and selective progesterone receptor modulator for the treatment of endometriosis: a comparison study in mice.
|
29615065 |
2018 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Progesterone receptor +331G/A polymorphism in endometriosis and deep-infiltrating endometriosis.
|
18281038 |
2008 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A comparison of PR and AR mRNA levels in the pelvic peritoneum of the endometriosis and the nonendometriosis groups revealed no significant differences.
|
7805924 |
1995 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The molecular basis of progesterone resistance in endometriosis may be related to an overall reduction in the levels of progesterone receptor (PR).
|
20108182 |
2010 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In a case-control study, we examined the PROGINS polymorphism of the progesterone receptor gene in 131 Italian women affected by endometriosis diagnosed according to published criteria for the definition of the definite disease.
|
15272913 |
2004 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The molecular basis of progesterone resistance in endometriosis may be related to an overall reduction in the levels of progesterone receptors (PRs) and the lack of the PR isoform named progesterone receptor B (PR-B).
|
16406281 |
2006 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Analysis of in vivo PR-A and PR-B expression in endometrium from women with and without endometriosis.
|
16009159 |
2005 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study demonstrated that epigenetic changes occur in both promoter regions of the PGR gene in intestinal endometriosis.
|
24481237 |
2014 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Patients with endometriosis presented lower levels of progesterone receptor type B expression.
|
30638056 |
2019 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Androgens Upregulate Endometrial Epithelial Progesterone Receptor Expression: Potential Implications for Endometriosis.
|
28891417 |
2017 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the +331G/A progesterone receptor promoter polymorphism may modify the molecular epidemiologic pathway that encompasses both the development of endometriosis and its subsequent transformation into endometrioid/clear cell ovarian cancer.
|
15598772 |
2004 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
This indicates that PROGINS can be considered as a predisposing risk marker for breast cancer but not for endometriosis and uterine fibroids.
|
17522428 |
2007 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of mucin-1 in endometriosis endometrium correlated with progesterone receptor B involved in infertility.
|
25155819 |
2015 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genotypes P1P1, P1P2 and P2P2 (P2 representing the PROGINS polymorphism) of the progesterone receptor gene presented frequencies of 93.9%, 5.4% and 0.7%, respectively, in the women with endometriosis-associated infertility (p=0.2101, OR=0.51, 95% CI=0.24-1.09); 94.4%, 4.2% and 1.4%, respectively, in the patients with minimal/mild endometriosis (p=0.2725, OR=0.53, 95% CI=0.20-1.43); 93.5%, 6.5% and 0%, respectively, among the patients with moderate/severe endometriosis (p=0.3679, OR=0.49, 95% CI=0.18-1.31); 86.0%, 14.0% and 0%, respectively, in idiopathic infertile women (p=0.8146, OR=1.10, 95% CI=0.46-2.63); and 88.3%, 10.6% and 1.1%, respectively, in the control group.
|
21243274 |
2010 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We conclude that there is a significant correlation between PROGINS polymorphism and endometriosis.
|
21751163 |
2011 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Endometrial stromal progesterone receptor-A/progesterone receptor-B ratio: no difference between women with and without endometriosis.
|
20097334 |
2010 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.
|
20719308 |
2011 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the PR polymorphisms were determined in women with deep infiltrating endometriosis (n = 72), women with adenomyosis in the uterine wall (n = 40), gynaecological patients without symptomatic endometriosis (n = 102) and healthy females (n = 93).
|
16920727 |
2007 |