Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
The selective progesterone receptor modulator, ulipristal acetate, has been reported to decrease the size of leiomyomas in clinical trials.
|
30567472 |
2019 |
Uterine Fibroids
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we determined the expression of progesterone receptor and compared the expression level of progesterone-regulated genes (PRGs) in human myometrial cells from normal uteri (MyoN) versus uteri with UFs (MyoF) in response to progesterone.
|
31288815 |
2019 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, perilipin-2 (PLIN2) was identified as a critical target gene of the progesterone receptor; however, its function in the pathogenesis of fibroids is unknown.
|
31504629 |
2019 |
Uterine Fibroids
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significantly higher expression of CKS2 was found in ULMS tissues than in ULM tissues (P<0.01) and high CKS2 expression was associated with increased tumor size, low progesterone receptor expression and poor prognosis in patients with ULMS.
|
31452763 |
2019 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The purpose of this study was to analyze the effect of ERα-351 XbaI A/G, ERα-397 PvuII T/C, and progesterone receptor (PGR) PROGINS polymorphisms on the development of leiomyomas.
|
30390345 |
2019 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
Ulipristal acetate (UPA) a selective progesterone receptor (PR) modulator (SPRM) reduce the size of UFs, inhibit ovulation and lead to amenorrhea.
|
31754172 |
2019 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
Can asoprisnil, a selective progesterone receptor modulator, provide clinically meaningful improvements in heavy menstrual bleeding (HMB) associated with uterine fibroids with an acceptable safety profile?
|
30865281 |
2019 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
The past, present, and future of selective progesterone receptor modulators in the management of uterine fibroids.
|
29274830 |
2018 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
Selective Progesterone Receptor Modulators for the Medical Treatment of Uterine Fibroids with a Focus on Ulipristal Acetate.
|
30539001 |
2018 |
Uterine Fibroids
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To evaluate progesterone receptor (PR), epithelial growth factor receptor (EGF-R), and galectin-3 expression in LMs, ALMs, STUMPs, and leiomyosarcomas and to assess their possible role in differentiating those tumors.
|
29729689 |
2018 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Conversely, the highest RANKL levels were found in the PR-rich leiomyoma intermediate cell (LIC) population.
|
29741640 |
2018 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MEDLINE using PubMed, Science Direct, and Google Scholar databases was searched using the terms "PROGINS," "progesterone receptor," "polymorphism," and "leiomyoma."
|
29630404 |
2018 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The history and use of the progesterone receptor modulator ulipristal acetate for heavy menstrual bleeding with uterine fibroids.
|
28169130 |
2017 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
Transthoracic needle biopsy was performed and the resected lesion consisted of benign spindle cells was positive for estrogen receptor (ER) and progesterone receptor (PR) and was diffuse positive for actin and desmin by immunohistochemical (IHC) staining, suggesting leiomyoma.
|
28203428 |
2017 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Uterine fibroids (UFs) may be treated with progesterone receptor modulators (PRMs), which have been shown to reduce heavy menstrual bleeding and the size of UFs.
|
28185997 |
2017 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, treatment with selective progesterone receptor modulators has shown promising results with shrinkage of uterine leiomyomas and a prolonged clinical effect.
|
28697115 |
2017 |
Uterine Fibroids
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our analyses identified secreted Frizzled-related protein 4 (sFRP4) as a key gene product functionally linked to PR activation whose expression was 2.6 times higher in leiomyomas than myometrium (n = 26, P < 0.01) and 2.5 times higher during the proliferative phase of the menstrual cycle (n = 26, P < 0.01).
|
28637297 |
2017 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The TC genotype of the ERβ receptor polymorphism and the GA and AA genotypes of the PGR receptor polymorphism and their respective hormonal levels can be developed as markers in the prediction of uterine fibroids.
|
26715264 |
2016 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
Progesterone receptor modulators, such as mifepristone are useful and well tolerated in reducing leiomyoma volume although with large individual variation.
|
24324590 |
2013 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
Studies testing various selective progesterone receptor modulators for the treatment of leiomyomas are also highlighted.
|
21672608 |
2012 |
Uterine Fibroids
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Gene and protein expression of progesterone receptor isoforms A and B, p53 and p21 in myometrium and uterine leiomyoma.
|
22350293 |
2012 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrated previously that LAT2 is a progesterone receptor target gene involved in leiomyoma growth.
|
20601542 |
2010 |
Uterine Fibroids
|
0.100 |
AlteredExpression
|
group |
BEFREE |
RU486 stimulated recruitment of Sp1, RNA polymerase II, PR, and the coactivators SRC-1 and SRC-2 to the distal region and basal promoter. siRNA knockdown of PR increased KLF11 expression, whereas knockdown of KLF11 increased leiomyoma cell proliferation and abolished the antiproliferative effect of RU486.
|
20124487 |
2010 |
Uterine Fibroids
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The present study was conducted to elucidate whether progesterone affects IGF-I mRNA through progesterone receptor B(PRB) mRNA in leiomyoma.
|
19499404 |
2009 |
Uterine Fibroids
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Leiomyoma progesterone receptor mRNA levels were significantly higher in Japanese women compared with African-American or Caucasian-American women.
|
19240151 |
2009 |