Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To this end, we used an inducible siRNA (small interfering RNA) expression system to silence the expression of MRP1 and MDR1 in human neuroblastoma SH-SY5Y cells.
|
18713069 |
2009 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The role, if any, of increased expression of mdr-1 in the acquisition of multidrug resistance in neuroblastoma remains unclear.
|
2185879 |
1990 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To rule out the possibility that multidrug resistance (MDR) genes are involved in development of acquired drug resistance in murine neuroblastoma (rMNB/MDL) cells made resistant to MDL, the expression of Mdr1a, Mdr1b, Mdr2 (multidrug resistance/P-glycoprotein), and Mrp-1 (multidrug resistance associated protein) was examined in rMNB-MDL cells.
|
11172599 |
2001 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Though Pgp expression is detectable and functional in neuroblastoma cells, but its presence does not provide much information to the complex phenomenon of chemotherapy resistance in patients.
|
9818076 |
1998 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A similar strong association has been observed between the expression of P-glycoprotein and outcome of treatment in certain malignancies in children, such as neuroblastoma, rhabdomyosarcoma, and acute lymphoblastic leukemia.
|
7642465 |
1995 |
Neuroblastoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Data from present study suggest that transcriptional inactivation of MDR1 gene due to increased MDR1 promoter methylation may be a contributing factor in pathogenesis and progression of neuroblastoma tumors, and may be used in designing an effective treatment therapy to neuroblastoma patients.
|
17387584 |
2007 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of the N-myc oncogene in neuroblastoma cell lines SH-SY5Y and BE(2)-C, following treatment with retinoic acid, was paralleled by down-regulation of MRP gene expression, contrasting with increased expression of the MDR1 gene.
|
7923112 |
1994 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
For the 26 treated neuroblastomas, the number of nonresponsive tumors was found to be significantly higher among those with high levels of MDR1 mRNA.
|
2778826 |
1989 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of N-myc, c-myc, and MDR-1 proteins in newly established neuroblastoma cell lines: a study by immunofluorescence staining and flow cytometry.
|
1374683 |
1992 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts.
|
8761367 |
1996 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to determine the activity of pyrazoloacridine (PZA) in neuroblastomas that have acquired high-level resistance to multiple drugs (not associated with multidrug resistance-associated protein or P-glycoprotein) during therapy, including those with loss of p53 function.
|
12960142 |
2003 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lovastatin, a nonreversible inhibitor of HMG-CoA reductase, induced extensive cytotoxicity that was restricted to drug-resistant P-glycoprotein-expressing neuroblastoma cell lines.
|
8612233 |
1996 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Study of the mechanisms underlying the reversal of multidrug resistance of human neuroblastoma multidrug-resistant cell line SK-N-SH/MDR1 by low-intensity pulsed ultrasound.
|
23483136 |
2013 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A panel of monoclonal antibodies (MAbs) to P-glycoprotein was developed by immunization of mice with multidrug-resistant human neuroepithelioma and neuroblastoma cells.
|
1348013 |
1992 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest a clinical role for the MDR1 gene in specific subgroups of primary neuroblastoma.
|
9516848 |
1997 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that most neuroblastoma cell lines are sensitive to YM155 in the low nM range and that resistant cells can be sensitised by ABCB1 inhibitors.
|
22088485 |
2012 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Before chemotherapy, only 10% of the NB samples showed positivity for P-gp.
|
9317175 |
1997 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of mdr1/P-glycoprotein and p110 in neuroblastoma.
|
7891222 |
1995 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, the synergy was based on a lapatinib induced inhibition of the multidrug-resistance efflux transporter ABCB1, which is frequently expressed in resistant neuroblastoma cells, which allowed prolonged and elevated cytotoxicity of YM155.In addition, the drug combination (i.e. lapatinib plus YM155) decreased neuroblastoma tumor size in an in vivo model.
|
28596528 |
2017 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study offers compelling evidence that (a) IGR-N-91 is a human neuroblastoma xenograft model able to induce metastasis in nude mice, (b) an increase in MYCN and MDR1 transcripts levels is associated with the metastatic process, and (c) IGR-N-91 provides a biological tool for the study of gene activations during tumor dissemination in neuroblastoma.
|
8174136 |
1994 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hypermethylation of the miR-137 promoter and negative regulation of miR-137 by CAR contribute in part to reduced miR-137 expression and increased CAR and MDR1 expression in doxorubicin-resistant neuroblastoma cells.
|
23934188 |
2014 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate upregulation of multidrug transporters ABCB1 and ABCG2 as a major mode of resistance to THZ1, a covalent inhibitor of CDKs 7, 12, and 13 in neuroblastoma and lung cancer.
|
29276047 |
2018 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results show that BS-RNase selectively kills NB cells by inducing apoptosis and that this agent is active against mdr-1 expressing cells both in vitro and in vivo.
|
10536185 |
1999 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MDR1 RNA levels were occasionally elevated in other untreated cancers, including neuroblastoma, acute lymphocytic leukemia (ALL) in adults, acute nonlymphocytic leukemia (ANLL) in adults, and indolent non-Hodgkin's lymphoma.
|
2562856 |
1989 |
Neuroblastoma
|
0.400 |
PosttranslationalModification
|
disease |
LHGDN |
Data from present study suggest that transcriptional inactivation of MDR1 gene due to increased MDR1 promoter methylation may be a contributing factor in pathogenesis and progression of neuroblastoma tumors, and may be used in designing an effective treatment therapy to neuroblastoma patients.
|
17387584 |
2007 |