Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A panel of monoclonal antibodies (MAbs) to P-glycoprotein was developed by immunization of mice with multidrug-resistant human neuroepithelioma and neuroblastoma cells.
|
1348013 |
1992 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of N-myc, c-myc, and MDR-1 proteins in newly established neuroblastoma cell lines: a study by immunofluorescence staining and flow cytometry.
|
1374683 |
1992 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Because expression of mdr-1 is increased in neuroblastoma cell lines by differentiating agents, the authors hypothesized a similar correlation with differentiation in vivo in neuroblastomas.
|
1678252 |
1991 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MDR1 mRNA transcription may occur spontaneously after onset, suggesting that certain NB tumors could be resistant to antineoplastic drugs at onset.
|
1974410 |
1990 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The role, if any, of increased expression of mdr-1 in the acquisition of multidrug resistance in neuroblastoma remains unclear.
|
2185879 |
1990 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Many of the neuroblastoma samples were also evaluated for N-myc amplification but there was no correlation between N-myc copy number and the level of MDR1 mRNA expression.
|
2295903 |
1990 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MDR1 RNA levels were occasionally elevated in other untreated cancers, including neuroblastoma, acute lymphocytic leukemia (ALL) in adults, acute nonlymphocytic leukemia (ANLL) in adults, and indolent non-Hodgkin's lymphoma.
|
2562856 |
1989 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
An increase in the level of mdr1 mRNA was observed after retinoic acid treatment of four neuroblastoma cell lines, including the SK-N-SH cell line.
|
2573830 |
1989 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
For the 26 treated neuroblastomas, the number of nonresponsive tumors was found to be significantly higher among those with high levels of MDR1 mRNA.
|
2778826 |
1989 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A similar strong association has been observed between the expression of P-glycoprotein and outcome of treatment in certain malignancies in children, such as neuroblastoma, rhabdomyosarcoma, and acute lymphoblastic leukemia.
|
7642465 |
1995 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of mdr1/P-glycoprotein and p110 in neuroblastoma.
|
7891222 |
1995 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of the N-myc oncogene in neuroblastoma cell lines SH-SY5Y and BE(2)-C, following treatment with retinoic acid, was paralleled by down-regulation of MRP gene expression, contrasting with increased expression of the MDR1 gene.
|
7923112 |
1994 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study offers compelling evidence that (a) IGR-N-91 is a human neuroblastoma xenograft model able to induce metastasis in nude mice, (b) an increase in MYCN and MDR1 transcripts levels is associated with the metastatic process, and (c) IGR-N-91 provides a biological tool for the study of gene activations during tumor dissemination in neuroblastoma.
|
8174136 |
1994 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lovastatin, a nonreversible inhibitor of HMG-CoA reductase, induced extensive cytotoxicity that was restricted to drug-resistant P-glycoprotein-expressing neuroblastoma cell lines.
|
8612233 |
1996 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts.
|
8761367 |
1996 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Before chemotherapy, only 10% of the NB samples showed positivity for P-gp.
|
9317175 |
1997 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest a clinical role for the MDR1 gene in specific subgroups of primary neuroblastoma.
|
9516848 |
1997 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Though Pgp expression is detectable and functional in neuroblastoma cells, but its presence does not provide much information to the complex phenomenon of chemotherapy resistance in patients.
|
9818076 |
1998 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results show that BS-RNase selectively kills NB cells by inducing apoptosis and that this agent is active against mdr-1 expressing cells both in vitro and in vivo.
|
10536185 |
1999 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To rule out the possibility that multidrug resistance (MDR) genes are involved in development of acquired drug resistance in murine neuroblastoma (rMNB/MDL) cells made resistant to MDL, the expression of Mdr1a, Mdr1b, Mdr2 (multidrug resistance/P-glycoprotein), and Mrp-1 (multidrug resistance associated protein) was examined in rMNB-MDL cells.
|
11172599 |
2001 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Factors secreted by human neuroblastoma mediated doxorubicin resistance by activating STAT3 and inhibiting apoptosis.
|
11474132 |
2001 |
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sections from formalin-fixed paraffin-embedded tumor blocks from 52 neuroblastoma cases (17 with localized, 35 with advanced disease) were subjected to immunohistochemistry for P-gp and GST-pi expressions.
|
12078865 |
2002 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Meningioma cells frequently co-expressed P-gp and MRP1, while, most of the neuroblastoma cell lines express higher P-gp but lower MRP1 levels as compared to the other tumor types.
|
12125964 |
2002 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to determine the activity of pyrazoloacridine (PZA) in neuroblastomas that have acquired high-level resistance to multiple drugs (not associated with multidrug resistance-associated protein or P-glycoprotein) during therapy, including those with loss of p53 function.
|
12960142 |
2003 |
Neuroblastoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Data from present study suggest that transcriptional inactivation of MDR1 gene due to increased MDR1 promoter methylation may be a contributing factor in pathogenesis and progression of neuroblastoma tumors, and may be used in designing an effective treatment therapy to neuroblastoma patients.
|
17387584 |
2007 |