|
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
CRC risk associated with ever MHT use as well as with duration was significantly modified by rs1202168 in the transporter gene ABCB1 (P interaction=0.04).
|
21490239 |
2011 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Colorectal cancers are often chemoresistant toward antitumour drugs that are substrates for ABCB1-mediated multidrug resistance (MDR).
|
22460269 |
2012 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
P-glycoprotein (P-gp) is a 170 kDa transmembrane glycoprotein which plays a significant role in modulating pleomorphic or multiple drug resistance (MDR) in a wide variety of human cancers like renal and colorectal carcinoma.
|
10630353 |
1999 |
|
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer.
|
16702732 |
2006 |
|
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
ABCB1 gene polymorphisms and expression of P-glycoprotein and long-term prognosis in colorectal cancer.
|
19192650 |
2009 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
P-glycoprotein was distributed over the luminal surface of the colorectal carcinoma.
|
1977924 |
1990 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
ABCB1, diet, and gut microbes mutually interact in colonic inflammation, a well-known risk factor for CRC.
|
26557010 |
2015 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells.
|
31487863 |
2019 |
|
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
MDR1 gene expression in primary colorectal carcinomas.
|
8398695 |
1993 |
|
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
MDR1 expression correlates with mutant p53 expression in colorectal cancer metastases.
|
8898977 |
1996 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
P-glycoprotein is positively correlated with p53 protein accumulation in human colorectal cancers.
|
9330605 |
1997 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
MDR1 RNA transcripts do not indicate long-term prognosis in colorectal carcinomas.
|
9337699 |
1997 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
AFP promoter-driven anti-MDR1 ribozymes reduced the IC(50) 30-fold for epirubicin in HCC cells, whereas human colorectal cancer cells were unaffected.
|
12297834 |
2002 |
|
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between MDR1 C3435T polymorphism and colorectal cancer risk: A meta-analysis.
|
29390571 |
2017 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1.
|
30306567 |
2019 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer.
|
24901713 |
2014 |
|
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Collectively, the results of the present study suggest that there were no significant associations of ABCB1/MDR1 C3435T polymorphism with colorectal cancer observed for all comparison models.
|
23504525 |
2013 |
|
Colorectal Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Combined PC and CRC signature or "combined cancer signature" was derived to differentiate either CRC and PC from controls (MDR1, SRBC, VHL, MUC2, RB1, SYK and GPC3) AUC = 0.8177, Sens = 0.6316 Spec = 0.840.
|
24288256 |
2014 |
|
Colorectal Carcinoma
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer.
|
21296766 |
2011 |
|
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer.
|
19415305 |
2009 |
|
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
DTA0100 mitotic arrest properties were investigated in two multi-drug resistant cancer cell lines with P-glycoprotein overexpression (colorectal carcinoma and glioblastoma).
|
28502672 |
2017 |
|
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Effect of ionizing radiation on transcription of colorectal cancer MDR1 gene of HCT-8 cells.
|
23608383 |
2013 |
|
Colorectal Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans.
|
16800822 |
2006 |
|
Colorectal Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression of the mdr1 gene in human colorectal carcinomas: relationship with multidrug resistance inferred from analysis of human colorectal carcinoma cell lines.
|
1537074 |
1992 |