Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy.
|
26122019 |
2016 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
C3435T polymorphism of MDR1 gene was analysed by the high resolution melting technique in a group of patients with drug-resistant (n = 106) and drug-responsive epilepsy (n = 67), as well as in non-epileptic children (n = 98) hospitalised at the Department of Neurology, Polish Mother's Memorial Hospital in Lodz.
|
27391700 |
2016 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Conflicting reports suggest a possible association between variants of the MDR1 gene and medical intractability in epilepsy.
|
15679503 |
2005 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We included all published studies until September 2007, in which patients with responsive and unresponsive seizure disorders underwent genotyping for ABCB1 C3435T.
|
19178561 |
2009 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Further analysis using a logistic regression model revealed that only 2677G>T and 3435C>T in the ABCB1 gene and their interaction term were associated with drug-resistant epilepsy after adjustment for etiology and epilepsy classification.
|
17924830 |
2007 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our finding disproves a general association between ABCB1 polymorphisms and drug response in epilepsy patients.
|
20417680 |
2010 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The study failed to corroborate association between polymorphism CYP3A5*3 and C3435T polymorphism in MDR1 gene and pharmacoresistant epilepsy.
|
23984379 |
2013 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied the association between C3435T and G2677T/A ABCB1 gene polymorphisms and drug resistance in Iranian epilepsy patients.
|
21636342 |
2011 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Significance of MDR1 gene polymorphism C3435T in predicting drug response in epilepsy.
|
24300029 |
2014 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association between the non-synonymous polymorphism G2677T/A in the coding region of the ABCB1 gene, and the risk of resistance to anti-epileptic drugs (AEDs) in epilepsy remains controversial.
|
26220385 |
2015 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts.
|
19453704 |
2009 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The analysis showed that there were significantly more cases with the MDR1 3435 CC genotype in the group with drug-resistant epilepsy than in the group with drug-responsive epilepsy [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.06, P=0.01].
|
24953225 |
2014 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ABCB1 gene C3435T polymorphism and drug resistance in epilepsy: evidence based on 8,604 subjects.
|
25799371 |
2015 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previous studies reported the associations between the ATP-binding cassette sub-family B member 1 (ABCB1, also known as MDR1) polymorphisms and their haplotypes with risk of response to antiepileptic drugs in epilepsy, however, the results were inconclusive.
|
25816099 |
2015 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, we performed the first haplotype meta-analysis to examine the association of haplotypes of ABCB1 common variants with the response to treatment in epilepsy.
|
21391884 |
2011 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
rs776746 and rs15524 in the CYP3A5 gene tend to affect CBZ metabolism, and rs2032582, rs10234411 in the ABCB1 gene may contribute to inter-individual variation in CBZ and in CBZ-E transport among patients with epilepsy using CBZ in combination with PHT or PB.
|
26421491 |
2015 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The genetic polymorphism of ABCB1 rs1045642 was found to be associated with normalized OXC concentration and therapeutic efficacy in patients with epilepsy (P<0.05).
|
28837897 |
2017 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the P-glycoprotein-encoding gene ABCB1 are suspected to be associated with pharmacoresistance phenotypes in epilepsy patients.
|
22033938 |
2011 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
As compared with patients with drug-responsive epilepsy, patients with drug-resistant epilepsy were more likely to have the CC genotype at ABCB1 3435 than the TT genotype (odds ratio, 2.66; 95 percent confidence interval, 1.32 to 5.38; P=0.006).
|
12686700 |
2003 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey.
|
17917461 |
2008 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Since P-glycoproteins control the extrusion of a broad range of toxins and xenobiotics and are responsible for drug resistance in many diseases including cancer and brain diseases such as epilepsy, we propose that the failure of NDGA in maintaining glutamate uptake upregulated in SOD1-G93A mice and its therapeutic inefficacy are due to acquired pharmacoresistance mediated by the increased expression of P-glycoprotein.
|
18625223 |
2008 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Gene-wide tagging study of association between ABCB1 polymorphisms and multidrug resistance in epilepsy in Han Chinese.
|
19450124 |
2009 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ABCB1 3435C>T polymorphism and type of epilepsy were associated with response to PB.
|
25846690 |
2015 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to investigate the effect of the 1236C>T(rs1128503), 2677G>T/A(rs2032582), and 3435C>T(rs1045642) single-nucleotide polymorphisms of ABCB1 (or MDR1) on drug resistance in north Indian patients with epilepsy.
|
18812236 |
2009 |
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings rule out the MDR1 c.3435C>T polymorphism having a major role or increasing the risk of drug-resistance suggesting a revision is required to determine the contribution of this polymorphism in predicting drug response in epilepsy.
|
25458099 |
2015 |