|
Epilepsy
|
0.600 |
Biomarker
|
disease |
CTD_human |
In epileptic brain specimens with high MDR1 mRNA levels, expression of P-glycoprotein in astrocytes also was identified.
|
8001500 |
1995 |
|
Epilepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
ABCB1 3435 was genotyped in 315 patients with epilepsy, classified as drug-resistant in 200 and drug-responsive in 115, and 200 control subjects without epilepsy.
|
12686700 |
2003 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
As compared with patients with drug-responsive epilepsy, patients with drug-resistant epilepsy were more likely to have the CC genotype at ABCB1 3435 than the TT genotype (odds ratio, 2.66; 95 percent confidence interval, 1.32 to 5.38; P=0.006).
|
12686700 |
2003 |
|
Epilepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
It has therefore been proposed that MDR1/PgP may contribute to multiple drug resistance in epilepsy.
|
12699350 |
2003 |
|
Epilepsy
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy.
|
14984901 |
2004 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Conflicting reports suggest a possible association between variants of the MDR1 gene and medical intractability in epilepsy.
|
15679503 |
2005 |
|
Epilepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Selective inhibitors of the major efflux transporter P-glycoprotein are currently in clinical trials for reversing chemotherapy resistance in oncology and may soon be used to determine whether such inhibitors can prevent or reverse drug resistance in epilepsy.
|
16120487 |
2005 |
|
Epilepsy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Recent evidence suggests that the homozygous C-variant, which is associated with higher expression and increased activity of P-gp, is more common in patients with pharmacoresistant epilepsy.
|
15857428 |
2005 |
|
Epilepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
We aimed to determine the effect of the ABCB1 gene on epilepsy drug response, using a unique large cohort of epilepsy patients with prospectively measured seizure and drug response outcomes.
|
16857572 |
2006 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between C3435T nucleotide MDR1 genetic polymorphism and multidrug-resistant epilepsy.
|
16542858 |
2006 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs at nucleotide position 1236 in exon 12, 2677 in exon 21 and 3435 in exon 26 of the MDR1 gene were genotyped in 207 Korean epileptics.
|
16386926 |
2006 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients.
|
16753003 |
2006 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Further analysis using a logistic regression model revealed that only 2677G>T and 3435C>T in the ABCB1 gene and their interaction term were associated with drug-resistant epilepsy after adjustment for etiology and epilepsy classification.
|
17924830 |
2007 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previous attempts to correlate the ABCB1 C3435T SNP, or a three-SNP haplotype containing C3435T with epilepsy pharmacoresistance have produced discordant findings.
|
17460550 |
2007 |
|
Epilepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Lessons learnt from the ABCB1 studies can help guide future association genetics studies, both for multidrug resistance in epilepsy, and for other epilepsy phenotypes.
|
17661727 |
2007 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ABCB1 3435C>T was genotyped in 746 Han Chinese patients with epilepsy and 179 controls.
|
17521963 |
2007 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Further analysis using a logistic regression model revealed that only 2677G>T and 3435C>T in the ABCB1 gene and their interaction term were associated with drug-resistant epilepsy after adjustment for etiology and epilepsy classification.
|
17924830 |
2007 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
ABCB1 3435C>T was genotyped in 746 Han Chinese patients with epilepsy and 179 controls.
|
17521963 |
2007 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey.
|
17917461 |
2008 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Since P-glycoproteins control the extrusion of a broad range of toxins and xenobiotics and are responsible for drug resistance in many diseases including cancer and brain diseases such as epilepsy, we propose that the failure of NDGA in maintaining glutamate uptake upregulated in SOD1-G93A mice and its therapeutic inefficacy are due to acquired pharmacoresistance mediated by the increased expression of P-glycoprotein.
|
18625223 |
2008 |
|
Epilepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
P-glycoprotein (Pgp), a transmembrane transporter encoded by ABCB1 gene and located at the endothelial cells of the blood-brain barrier (BBB), has been associated with epilepsy pharmacoresistance.
|
18329296 |
2008 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene.
|
18436433 |
2008 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey.
|
17917461 |
2008 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We included all published studies until September 2007, in which patients with responsive and unresponsive seizure disorders underwent genotyping for ABCB1 C3435T.
|
19178561 |
2009 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts.
|
19453704 |
2009 |