|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We show that exposure of leukemia cells to daunorubicin activated an integrated stress response-like transcriptional program to induce ABCB1 through remodeling and activation of an ATF4-bound, stress-responsive enhancer.
|
31770110 |
2020 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
For this purpose, human leukemia K562 cells with varying expression levels of ABCB1 were used: drug selected K562/Dox and K562/HHT cells with very high transporter expression, and K562/DoxDR2, K562/DoxDR1, and K562/DoxDR05 cells with gradually decreased expression of ABCB1 derived from K562/Dox cells using RNA interference technology.
|
31209929 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These may include increased production of tumor resistance conferring proteins such as multidrug resistance (MDR-1) and myeloid cell leukemia (MCL-1).
|
30452910 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ceritinib Enhances the Efficacy of Substrate Chemotherapeutic Agent in Human ABCB1-Overexpressing Leukemia Cells In Vitro, In Vivo and Ex-Vivo.
|
29742496 |
2018 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
P-glycoprotein (P-gp) is an important multidrug resistance (MDR) regulator for leukemia to mediate its development and thus can be considered as a powerful reference for the diagnosis of MDR.
|
29996649 |
2018 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, long noncoding RNA (lncRNA) UCA1 was identified as an important modulator of MDR1 by a model system of leukemia cell lines with a gradual increase of MDR1 expression and IM resistance.
|
27854515 |
2017 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein.
|
29121121 |
2017 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, human leukemia K562 cells expressing various levels of ABCB1 were used.
|
28623111 |
2017 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Treatment of leukaemia cells with 3p-siRNA-MDR1 down-regulated MDR1 expression, reduced-drug resistance and induced immune and pro-apoptotic effects in drug-resistant HL-60/Adr and K562/Adr human leukaemia cell lines.
|
28380403 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cytotoxic studies have demonstrated a higher sensitivity of the leukemia lines to DOX-BNNPs compared with the carcinoma lines: IC<sub>50</sub>(DOX-BNNPs) is 1.13, 4.68, 0.025, and 0.14 μg/mL for the KB-3-1, MDR KB-8-5, K562, and MDR i-S9 cell lines, respectively.
|
28857548 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, whether epigenetic mechanisms contribute specifically to doxorubicin resistance in leukemia has not been carefully examined.
|
26317407 |
2016 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of P-glycoprotein in leukemia cells is associated with the upregulated expression of nestin, a class 6 filament protein.
|
27479651 |
2016 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effects of APO866 with or without Pgp inhibitors were tested on the viability of leukemia cell lines, primary leukemia cells (AML, n = 6; B-CLL, n = 19), and healthy leukocytes.
|
25964294 |
2015 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
ATP-binding cassette subfamily B member 1 (ABCB1) is a recognized factor which causes MDR and is closely related to poor outcome and relapse in leukemia.
|
26062728 |
2015 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study investigated whether SFRP5 gene methylation causes multidrug resistance (MDR) in leukemia through the Wnt/ß-catenin signaling, leading to the upregulation of the mdr1 gene and its product, P-glycoprotein (P-gp).
|
24434572 |
2014 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between the MDR1 G2677T polymorphism and leukemia risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CI).
|
24142546 |
2014 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the MDR1 C3435T polymorphism associate with risk of leukaemia.
|
23731124 |
2013 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells.
|
23999162 |
2013 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, two GO-resistant variants (HL/GO-CSA [225-fold], HL/GO [200-fold]) were established by serially incubating human leukemia HL-60 cells with GO with or without a P-glycoprotein (P-gp) inhibitor, cyclosporine A, respectively.
|
22632031 |
2012 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, apatinib also strongly reversed multidrug resistance (MDR) in K562/ADR cells, and the primary leukemia blasts overexpressing ABCB1 while showed no synergistic interactions with chemotherapeutic agents in MRP1-, MRP4-, MRP7- and LRP-overexpressing cells.
|
22212563 |
2012 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings provide further evidence that the MDR1 C3435T variant may modify the susceptibility to leukemia.
|
22088099 |
2012 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bortezomib is a promising potential therapy for acute leukemia, especially mdr1 drug-resistant leukemia.
|
22145750 |
2012 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is known that the drug efflux protein, P-glycoprotein (P-gp), and inhibitors of apoptosis proteins (IAPs) are involved in the MDR of leukemic cells, but their roles in leukemia infiltration have not been clearly elucidated.
|
21599575 |
2011 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, it had no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells and multidrug resistance-related protein 1-mediated doxorubicin resistance in MRP1-transfected human epidermoid cancer KB-3-1 cells.
|
21566063 |
2011 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have identified a novel MDR1 (GT1292-3TG) (Cys431Leu) genetic variation through systematic profiling of subjects with leukemia.
|
20623213 |
2010 |