Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
We tested whether the uremic toxin indoxyl sulfate (IS), an endogenous ligand of the transcription factor aryl hydrocarbon receptor, could change the expression of the following liver transporters involved in drug clearance: <i>SLC10A1</i>, <i>SLC22A1</i>, <i>SLC22A7</i>, <i>SLC47A1</i>, <i>SLCO1B1</i>, <i>SLCO1B3</i>, <i>SLCO2B1</i>, <i>ABCB1</i>, <i>ABCB11</i>, <i>ABCC2</i>, <i>ABCC3</i>, <i>ABCC4</i>, <i>ABCC6</i>, and <i>ABCG2</i> We showed that IS increases the expression and activity of the efflux transporter P-glycoprotein (P-gp) encoded by <i>ABCB1</i> in human hepatoma cells (HepG2) without modifying the expression of the other transporters.
|
29222397 |
2018 |
Liver neoplasms
|
0.300 |
Biomarker
|
group |
RGD |
Verapamil and rifampin effect on p-glycoprotein expression in hepatocellular carcinoma.
|
25625052 |
2014 |
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.
|
22363234 |
2012 |
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
A former study evaluated the roles of four multidrug resistance-related proteins, namely multidrug resistance protein 1 (MDR1), breast cancer resistance protein (BCRP), multidrug resistance-related protein (MRP1), and lung resistance-related protein (LRP), in the MDR mechanism of the multidrug resistant hepatoma HepG2/ADM cell line and proposed that up-regulated MDR1 and BCRP are responsible for the MDR of hepatocellular carcinoma.
|
20437864 |
2010 |
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of ABCB1 transporter by atorvastatin in a human hepatoma cell line and in human peripheral blood mononuclear cells.
|
16996216 |
2006 |
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Notwithstanding the differences of the investigated hepatoma cell lines in P-glycoprotein function, acetaminophen-induced toxicity was similar, possibly due to different functions of drug-metabolizing systems.
|
16930294 |
2006 |
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
BCT and TNF-alpha can reverse HCC MDR in nude mouse MDR1 model of liver neoplasm.
|
16237754 |
2005 |
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
LHGDN |
Up-regulation of lactosylceramide synthase in MDR1 overexpressing human liver tumour cells.
|
15936020 |
2005 |
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
The pro-oxidants H2O2 and buthionine sulfoximine down-regulated HIF-1alpha and P-gp, whereas up-regulation was achieved with the radical scavengers dehydroascorbate, N-acetylcysteine, and vitamin E. The correlation of HIF-1alpha and P-gp expression was validated by the use of hepatoma tumor spheroids that were either wild type (Hepa1) or mutant (Hepa1C4) for aryl hydrocarbon receptor nuclear translocator (ARNT), i.e., HIF-1beta.
|
12514119 |
2003 |
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
In this study, we report that 2-AAF could also activate the human MDR1 gene in human hepatoma and embryonic fibroblast 293 cells.
|
11960367 |
2002 |
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Inhibition of P-glycoprotein expression and reversal of drug resistance of human hepatoma HepG2 cells by multidrug resistance gene (mdr1) antisense RNA.
|
11057761 |
2000 |
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
There was no consistent increase or decrease in Pgp expression in secondary hepatic neoplasms compared with paired perineoplastic liver.(ABSTRACT TRUNCATED AT 250 WORDS)
|
7473127 |
1995 |
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
To evaluate the role of the MDR1 gene in the drug resistance of hepatoma, we tested nine human hepatoma cell lines for their expression of the MDR1 gene.
|
7908989 |
1994 |
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
The results indicate that the MDR1 gene is overexpressed in liver tumors and some preneoplastic lesions and that might account for the very poor response of primary liver cancers to chemotherapy.
|
8409332 |
1993 |
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Similarly, MDR1 messenger RNA levels were elevated in the Dex-treated human hepatoma line, HepG2, but not in the nonhepatoma, HeLa.
|
8102093 |
1993 |