Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated whether 9 SNPs in ABCB1 (rs6946119, rs28401781, rs4148739, and rs3747802), ABCB6 (rs1109866, rs1109867, rs3731885, and rs3755047), and ABCG1 (rs182694) contribute to the risk of SCZ in a Han Chinese population.
|
31189171 |
2019 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, to clarify the interindividual differences in the adverse effects of specific atypical antipsychotics in schizophrenia, we investigated the association between ANS dysfunction and ATP-binding cassette transport sub-family B member 1 (ABCB1) gene polymorphisms in patients with schizophrenia.
|
30016952 |
2018 |
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Many atypical antipsychotic drugs currently prescribed for the treatment of schizophrenia have limited brain penetration due to the efflux activity of ATP-binding cassette (ABC) transporters at the blood-brain barrier (BBB), including P-glycoprotein (P-gp) and ABCG2.
|
28264565 |
2017 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results imply that clozapine or non-P-gp substrate antipsychotic drugs may be better first-line treatments for schizophrenia patients with a history of cannabis use.
|
28272498 |
2017 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine the association between MDR1 gene polymorphisms and clinical characteristics in patients with schizophrenia.
|
24918524 |
2014 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Effect of risperidone metabolism and P-glycoprotein gene polymorphism on QT interval in patients with schizophrenia.
|
24589909 |
2014 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Effects of genetic polymorphisms of CYP2D6, CYP3A5, and ABCB1 on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in Japanese patients with schizophrenia.
|
24682161 |
2014 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
The aim of this study was to determine the association between MDR1 gene polymorphisms and clinical characteristics in patients with schizophrenia.
|
24918524 |
2014 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Effects of genetic polymorphisms of CYP2D6, CYP3A5, and ABCB1 on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in Japanese patients with schizophrenia.
|
24682161 |
2014 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Impact of the ABCB1 gene polymorphism on plasma 9-hydroxyrisperidone and active moiety levels in Japanese patients with schizophrenia.
|
23609388 |
2013 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Impact of the ABCB1 gene polymorphism on plasma 9-hydroxyrisperidone and active moiety levels in Japanese patients with schizophrenia.
|
23609388 |
2013 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Antipsychotic drug dosage and therapeutic response in schizophrenia is influenced by ABCB1 genotypes: a study from a south Indian perspective.
|
22909202 |
2012 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Genetic variation in ABCB1 may be associated with P300 amplitude in patients with schizophrenia.
|
22910404 |
2012 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in ABCB1 may be associated with P300 amplitude in patients with schizophrenia.
|
22910404 |
2012 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that ABCB1 genetic polymorphisms may be a predictive marker of quetiapine treatment in schizophrenia.
|
21148022 |
2011 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association study of MDR1 and 5-HT2C genetic polymorphisms and antipsychotic-induced metabolic disturbances in female patients with schizophrenia.
|
20195292 |
2011 |
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Increased P-gp activity may be a factor in drug resistance in schizophrenia, induced by the use of antipsychotic agents.
|
20620031 |
2010 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The role of CYP2D6 and ABCB1 pharmacogenetics in drug-naïve patients with first-episode schizophrenia treated with risperidone.
|
20563569 |
2010 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The impact of the UGT1A4, CYP1A2, and MDR1 genetic variants on olanzapine plasma levels, in relation to those of other individual factors, such as gender, smoking status, body weight, and age, was investigated in patients with schizophrenia.
|
20143052 |
2010 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present study does not suggest a major influence of MDR1 G2677T/A and C3435T polymorphisms on treatment response during short-term risperidone therapy in patients with schizophrenia or schizoaffective disorder.
|
20060871 |
2010 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In order to our knowledge, this is the first association study between the MDR1 polymorphism and polydipsia-hyponatremia in SCZ.
|
18543120 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Associations between MDR1 gene polymorphisms and schizophrenia and therapeutic response to olanzapine in female schizophrenic patients.
|
17113599 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients.
|
17054409 |
2006 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We, therefore, examined five SNPs of the MDR1 gene, -1517 T>C (promoter), -41 A>G (intron -1), -129 T>C (exon 1b), 2677 G>A,T (exon 21) and 3435 C>T (exon 26), in Japanese patients with schizophrenia (n=121) and mood disorders (n=62), and compared with the control subjects (n=160).
|
17142980 |
2006 |