Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
circKDM4C suppresses tumor progression and attenuates doxorubicin resistance by regulating miR-548p/PBLD axis in breast cancer.
|
31406252 |
2019 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrated that ECM remodeling during tumor progression increased CS chains to facilitate EMT and ABCB1 upregulation, contributing to chemoresistance acquisition.
|
30016638 |
2018 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Thirdly, we review evidence that P-gp activity is enhanced in the process of epithelial-to-mesenchymal transition (EMT), which is associated with cancer progression, without any increase in expression of P-gp mRNA.
|
29311472 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these results suggest that extracellular galectin-1 contributes to cancer progression and doxorubicin resistance in TNBC cells.
|
28415760 |
2017 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Additionally, P-glycoprotein (MDR1) and c-Myc, contributing to tumor progression, were suppressed by the nanoparticles, while p53 was improved in drug-resistant cells.
|
28958938 |
2017 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The resistance on HT-29 cell-derived matrices increased through the activation of Akt and the upregulation of ABCB1 and ABCC1 without cell growth promotion, suggesting that ECM remodeling plays important roles in the acquisition of chemoresistance during tumor progression.
|
27558478 |
2016 |
Tumor Progression
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
MDR1 gene could be activated via epigenetic mechanisms with demethylation of Line-1 in ESCC, and enhance tumor progression.
|
26823755 |
2015 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In the present study, a strong positive correlation between MDR1 and Anxa2 mRNA expression in invasive breast cancer tissues during cancer progression was observed.
|
24239898 |
2014 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, continuous PTX treatment caused the over-expression of P-gp and acquisition of MDR in colon cancer and glioblastoma cell lines, while some mechanisms of MDR and tumor progression such as GSH detoxification system and VEGF secretion were suppressed.
|
21775090 |
2011 |
Tumor Progression
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
The promoter methylation of MDR1 seems to have a significant role in carcinogenesis and tumor progression in the stomach.
|
19331170 |
2009 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that MDR1/P-gp expression may have an important role to play in tumor progression in the cases of soft tissue sarcoma, and p53 may be one of the active regulators of the MDR1 transcript.
|
15609299 |
2005 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity.
|
15042610 |
2004 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We studied the role of caveolin-1 in tumor progression and prognosis in serous ovarian carcinoma and the association between caveolin-1 and MDR1 expression.
|
11863219 |
2002 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Expression of bcl-2 in testicular carcinoma: correlation with tumor progression and MDR1/Pgp.
|
9669816 |
1998 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The present results indicate that the MDR1 gene is not associated in NSCLC with tumor progression and drug resistance.
|
9066608 |
1997 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
However, there is growing evidence that regulation primarily takes place at the transcriptional level and that the process of tumour progression is related to activation of the MDR1 gene.
|
8898977 |
1996 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Within this panel, mdr1 mRNA biosynthesis and surface localisation of Pgp were assessed with respect to MDR functionality where the cell lines are representative of different clinical stages of tumour progression, metastatic potential and differentiation.
|
8098614 |
1993 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
No correlation was found between MDR1 or N-myc genes expression and tumor progression.
|
1974410 |
1990 |