Disease: Carcinoma breast stage IV ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.100 Biomarker disease BEFREE We tested our hypothesis using antiluciferase siRNA in luciferase-expressing metastatic breast cancer cells (MDA-MB-231-Luc-D3H2LN) and anti-ABCB1 siRNA against an efflux membrane protein, ABCB1, in doxorubicin (DOX)-resistant breast cancer cells (MCF-7/Adr). 30940690 2019
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.100 AlteredExpression disease BEFREE Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298. 22521303 2012
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.100 GeneticVariation disease BEFREE ABCB1 genotypes may be a predictor of paclitaxel activity as well as a prognostic factor in metastatic breast cancer patients. 18836089 2009
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.100 GeneticVariation disease BEFREE Because transduction of hematopoietic stem cells with the multidrug resistance 1 (MDR1) gene might circumvent this problem, we conducted a pilot study of MDR1 gene therapy against metastatic breast cancer. 17683514 2007
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.100 Biomarker disease BEFREE Retroviral integration site analysis and the fate of transduced clones in an MDR1 gene therapy protocol targeting metastatic breast cancer. 17907967 2007
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.100 AlteredExpression disease BEFREE MDR1 is upregulated in many tumors.We have previously detected activation of the MDR1 upstream promoter in metastatic breast cancer cells. 15986426 2005
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.100 Biomarker disease BEFREE Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients. 10430060 1999
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.100 Biomarker disease BEFREE In a pilot chemoprotection trial, autologous CD34+ cells from patients with metastatic breast cancer were exposed to a replication-incompetent retroviral vector carrying MDR-1 cDNA and then reinfused after HDCT. 9829734 1998
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.100 Biomarker disease BEFREE Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer. 7526902 1994
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.100 Biomarker disease BEFREE Reduced occurrence of mdr-1 amplification in stage-IV breast-cancer patients treated with tamoxifen compared with other endocrine treatments. 8094712 1993