|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
P-glycoprotein (P-gp) plays a significant role in multi-drug resistance (MDR) of cancer cells, resulting in the failure of cancer chemotherapy.
|
31751870 |
2020 |
|
Multiple Chronic Conditions
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Computational approaches examined molecular level interactions of both drugs with the SLC transporters [organic cation transporter 1 (OCT1), plasma membrane monoamine transporter (PMAT) and multi-drug and toxic compound extrusion proteins (MATE1)] and amisulpride with the ABC transporter (P-glycoprotein).
|
31842924 |
2019 |
|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study aimed to investigate the role of Multi-drug resistance gene (MDR1), Placental glutathione S-transferase-P1 (GSTP1), Lung resistance protein (LRP) and Ras association domain family member 1 (RASSF1A) in primary epithelial ovarian cancer (PEOC).
|
31579424 |
2019 |
|
Multiple Chronic Conditions
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of the study was to examine the effect of AS602801 on the expression of multi drug resistance protein 1 (MDR1).
|
30711936 |
2019 |
|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
Artemisinin derivatives exhibit multi-specific interactions with P-gp.
|
31301971 |
2019 |
|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the expression levels of genes involved in apoptosis (PI3 K, AKT, BCL2, BAX, p53, p21, PTEN, CASP3, CASP8, and CASP9), differentiation (PML-RAR and HDAC1), and multi-drug resistance (ABCB1 and ABCC1) were determined using quantitative real-time PCR.
|
28865123 |
2018 |
|
Multiple Chronic Conditions
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we demonstrate CRISPR-mediated editing of two CpG islands located within the promoter region of the MDR1 gene (Multi Drug Resistance 1).
|
29605859 |
2018 |
|
Multiple Chronic Conditions
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Second, over-expression of Pygo2 facilitated the expression of P-glycoprotein, which acts as a drug efflux pump, by promoting the transcription of Multi-drug resistance 1 (MDR1) at the MDR1 promoter loci, resulting in acceleration of the efflux of PTX.
|
28427190 |
2017 |
|
Multiple Chronic Conditions
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Further, si-HDAC8 can also inhibit the expression of multi-drug resistance gene 1 (MDR1).
|
28223126 |
2017 |
|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
P-glycoprotein (P-gp) is an essential protein of Multi-drug resistance 1 (MDR1).
|
28380412 |
2017 |
|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
Downregulation of hepatic multi-drug resistance protein 1 (MDR1) after copper exposure.
|
28805879 |
2017 |
|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, DTA0100 blocked the P-glycoprotein function in both multi-drug resistant cancer cell lines without inducing the increase in P-glycoprotein expression.
|
28502672 |
2017 |
|
Multiple Chronic Conditions
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Generalized multi-analytical (GMDR) approach was used to determine the influence of the combination of variants of genes encoding phase 0 (SLC22A16); phase I (CYP450, NQO1); phase II (GSTs, MTHFR, UGT2B15); and phase III (ABCB1) DMEs along with confounding factors on the response and toxicity of chemotherapeutic drugs in breast cancer patients.
|
26506825 |
2016 |
|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the drug transporters ABCG2, ABCB1 and ABCC1 have been majorly implicated in cancer drug resistance, recent studies have associated ABCC3 with multi drug resistance and poor clinical response.
|
27171227 |
2016 |
|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
This research is intended to compile the frequency distribution of the drug metabolizing enzyme, thiopurine methyl transferase(TPMT) and the drug transporter, Multi drug resistance(MDR1) which are involved in metabolism of many therapeutics such as thiopurines in inflammatory bowel disease(IBD).
|
27453281 |
2016 |
|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
P-glycoprotein (Pgp) mediated multi-drug resistance (MDR) is a major cause of failure in chemotherapy.
|
25481438 |
2015 |
|
Multiple Chronic Conditions
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study demonstrated that primary human osteosarcoma samples contained a SP of about 3.9% which overexpressed ABC transporters, including ABCA1, ABCB1, ABCB2 and ABCG2, which are associated with drug resistance and may have contributed to multi‑drug resistance of SP cells.
|
26300407 |
2015 |
|
Multiple Chronic Conditions
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By the detection of HBV infection, AFP and AST, the targets of biological behavior and the gene expression of multi-drug resistance gene 1 (MDR1) in hepatocellular carcinoma (HCC), we investigate characteristics of the expression of MDR1 in HCC and its relationship with HCC biological behavior.
|
26261589 |
2015 |
|
Multiple Chronic Conditions
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Silencing of microRNA-127 also significantly reduced the mRNA and protein expression levels of MDR1 and MRP1, which are major ATP-binding cassette (ABC) transporter linked to multi-drug resistance in cancer cells.
|
26261488 |
2015 |
|
Multiple Chronic Conditions
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, miR‑10a suppressed the cellular expression of P‑glycoprotein, multi‑drug resistance protein (MDR) 1, MDR‑associated protein 1, RhoE, B cell lymphoma‑2 and survivin in A549/DDP cells.
|
25586740 |
2015 |
|
Multiple Chronic Conditions
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PEITC inhibited cisplatin-resistant human SGC7901/DDP cell growth in a dose-dependent manner, causing increased apoptosis, ROS generation, glutathione depletion, accumulation of Rhodamine-123, decreased expression of P-glycoprotein and cell cycle arrest. mRNA and protein expression of the multi-drug resistance gene (MDR1), multi-drug resistance-associated protein (MRP1), excision repair cross-complementing gene 1 (ERCC1), survivin, and Mad2 was decreased, and phosphorylation of Akt and transcriptional activation of NF-κB were suppressed.
|
23956061 |
2014 |
|
Multiple Chronic Conditions
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specifically, these studies investigated the association of the efficacy of 5-HT3RAs and variants in the multi drug resistance 1 (MDR1) gene, 5-HT3A,B and C receptor genes and CYP2D6 gene.
|
21365391 |
2011 |
|
Multiple Chronic Conditions
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the influence of multi-drug resistance 1 (MDR1) gene codon 3435 polymorphisms on response to platinum-based chemotherapeutic regimens for advanced non small cell lung cancer (NSCLC).
|
22296372 |
2011 |
|
Multiple Chronic Conditions
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An association trend was observed for ABCB1-3435C > T, which is responsible for the multi-drug resistance (odds ratio (OR) = 1.96, 95% confidence interval (CI) 0.98-3.95, P = 0.057).
|
20368715 |
2011 |
|
Multiple Chronic Conditions
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RNA interference plays an important role on down-regulation of P-glycoprotein (P-gp), which is a drug efflux transporter overexpressed on multi-drug-resistant (MDR) tumor cells.
|
20600887 |
2010 |