|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that there might be an association between SERPINA1 gene polymorphisms and the risk of developing wheezing/school age asthma.
|
31298815 |
2019 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to analyze the distribution of AAT genotypes in asthmatic patients allergic to house dust mites (HDM), and to asses a possible association between these genotypes and severe asthma.
|
30410723 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
RGD |
Genetic influences on asthma susceptibility in the developing lung.
|
20118217 |
2010 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The findings of this study provide strong evidence that NOS1 gene with 14-AAT tandem repeats has a significant effect in asthmatic children.
|
20609134 |
2010 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
To identify new markers of asthma and COPD to implement in clinical practice, we genotyped for common genetic variants in the cystic fibrosis transmembrane conductance regulator (CFTR), alpha(1)-antitrypsin, and mannose-binding lectin (MBL) genes, and measured baseline fibrinogen and C-reactive protein (CRP) concentrations in up to 9245 adults randomly selected from the Danish general population.
|
20298391 |
2009 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
[Alpha 1 antitrypsin polymorphism associated to asthma and emphysema in a central Tunisian population].
|
18725338 |
2008 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
AAT heterozygoty does not seem to be an important risk factor of persistent airflow limitation in patients with asthma.
|
16476537 |
2006 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Patients with alpha 1-antitrypsin (AAT) deficiency, like those with asthma and chronic obstructive pulmonary disease, usually present with dyspnea, wheeze, and cough.
|
9126209 |
1997 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the occurrence of the M1(ala213) allele of alpha 1-antitrypsin differs in various ethnic groups and may play a role in asthma.
|
7913005 |
1994 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The binding activities of alpha 1-protease inhibitor and alpha 2-macroglobulin in asthmatic patients with the M phenotype for the alpha 1-protease inhibitor differed in their relationship to the values in control subjects with the same phenotype [less alpha 1-protease inhibitor for asthmatics (35.1 +/- 1.8) than for controls (42.9 +/- 2.0 kU/L) (P < 0.001); more alpha 2-macroglobulin for asthmatics (6.9 +/- 0.3) than for control subjects (5.9 +/- 0.4 kU/L) (P < 0.03)].
|
7682483 |
1993 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Asthmatic families (AFs) and normal families (NFs) were studied to determine the relationship between bronchial hyperresponsiveness and alpha 1-antitrypsin protease inhibitor phenotype.
|
2203615 |
1990 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Patients with alpha 1-antitrypsin variants also had much shorter smoking histories as compared with the MM group, and all reported histories of asthma in first-degree relatives, as compared with 66% among the MM patients.
|
2241445 |
1990 |