|
Malignant neoplasm of breast
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To test the therapeutic value of the maspin gene (SERPINB5) in breast cancer, we established a syngeneic breast tumor metastasis model.
|
12027560 |
2002 |
|
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To test the therapeutic value of the maspin gene (SERPINB5) in breast cancer, we established a syngeneic breast tumor metastasis model.
|
12027560 |
2002 |
|
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To test the therapeutic value of the maspin gene (SERPINB5) in breast cancer, we established a syngeneic breast tumor metastasis model.
|
12027560 |
2002 |
|
Narcolepsy
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association database developed in the Japanese Integrated Database Project.
|
19629137 |
2009 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The N-myc downstream regulated gene (NDRG) family of NDRG1, 2, 3, and mammary serine protease inhibitor (Maspin) gene are well-known modulators in the neoplasia process.
|
27589737 |
2016 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
At the level of cell cycle, they inhibit the expression of oncogenic cyclin D1, increase the expression of cyclin-dependent kinase inhibitors (p21, p27, and p57) and tumor suppressor genes (APC, ATM, PTEN, SERPINB5).
|
30257383 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Maspin is a member of the serine protease inhibitors and the maspin gene, a tumor suppressor gene, is down-regulated in a large fraction of prostate cancers.
|
15960601 |
2005 |
|
Adenocarcinoma
|
0.060 |
GeneticVariation
|
group |
LHGDN |
Maspin and p53 protein expression in gastric adenocarcinoma and its clinical applications.
|
18091326 |
2008 |
|
Stomach Carcinoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The genotypes of 836 unrelated Korean participants (including 430 with gastric cancer) were examined for 12 tag single-nucleotide polymorphisms (SNPs) and imputed for 178 SNPs in the maspin gene.
|
22962304 |
2012 |
|
Stomach Carcinoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that demethylation at the maspin gene promoter disrupts the cell-type-specific gene repression in both GNE and gastric cancer.
|
14578190 |
2003 |
|
Malignant neoplasm of stomach
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that demethylation at the maspin gene promoter disrupts the cell-type-specific gene repression in both GNE and gastric cancer.
|
14578190 |
2003 |
|
Malignant neoplasm of stomach
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The genotypes of 836 unrelated Korean participants (including 430 with gastric cancer) were examined for 12 tag single-nucleotide polymorphisms (SNPs) and imputed for 178 SNPs in the maspin gene.
|
22962304 |
2012 |
|
melanoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The 19 CpG sites of the maspin promoter region were extensively hypomethylated in HMV-I, a maspin-positive cell line, and those of the remaining four melanoma and NHEM cell lines were hypermethylated.
|
15086568 |
2004 |
|
Malignant neoplasm of mouth
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR.
|
27525723 |
2016 |
|
Malignant neoplasm of mouth
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer.
|
28339463 |
2017 |
|
Lip and Oral Cavity Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR.
|
27525723 |
2016 |
|
Lip and Oral Cavity Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer.
|
28339463 |
2017 |
|
Liver carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Haplotypes "T-C-A" and "C-C-C" (rs2289519 + rs2289520 + rs1455555) located in the SERPINB5 coding region had a decreased (AOR = 0.744; P = 0.031) and increased (AOR = 1.981; P = 0.001) HCC risk, respectively.
|
27221742 |
2016 |
|
Secondary malignant neoplasm of bone
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether maspin, when produced at endogenous levels, is capable of inhibiting metastasis to bone we transfected a bacterial artificial chromosome (BAC) genomic clone containing the maspin gene into PC-3 cells that aggressively metastasize to bone in an animal model.
|
18367129 |
2009 |
|
Intestinal metaplasia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The maspin gene promoter region of all GNE without IM was hypermethylated on both alleles whereas those with IM frequently represented the haploid type of hypomethylation status.
|
14578190 |
2003 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
CTD_human |
Two examples include the antimetastatic, tumor suppressor genes, desmocollin 3 (DSC3) and MASPIN, which are frequently silenced in this manner in human breast cancer.
|
16799634 |
2007 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
METABIRC and TCGA breast cancer cohort mRNA expression data analysis revealed that a high expression of the anti‑angiogenesis‑associated genes, THBS2, SERPINF1 and serpin family B member 5 (SERPINB5), and of the tumor suppressor gene, PTEN, was associated with a better overall survival (OS) of breast cancer patients.
|
31059004 |
2019 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Two examples include the antimetastatic, tumor suppressor genes, desmocollin 3 (DSC3) and MASPIN, which are frequently silenced in this manner in human breast cancer.
|
16799634 |
2007 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
METABIRC and TCGA breast cancer cohort mRNA expression data analysis revealed that a high expression of the anti‑angiogenesis‑associated genes, THBS2, SERPINF1 and serpin family B member 5 (SERPINB5), and of the tumor suppressor gene, PTEN, was associated with a better overall survival (OS) of breast cancer patients.
|
31059004 |
2019 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Reverse-transcriptase polymerase chain reaction of the maspin gene in the detection of bone marrow breast carcinoma cell contamination.
|
11596016 |
2001 |