|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
The role of insulin dependent NO synthesis in the impaired production of maspin in human breast cancer.
|
16491398 |
2006 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Finally, small interfering RNA (siRNA)-mediated knockdown of G9A and DNMT1 led to increased MASPIN expression in MDA-MB-231 cells, to levels that were supra-additive, verifying the importance of these enzymes in maintaining multiple layers of epigenetic repression in breast tumor cells.
|
16799634 |
2007 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression.
|
12789271 |
2003 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Toward re-expressing tumor suppresor gene maspin in breast cancer.
|
12533266 |
2002 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Proteomics demonstration that normal breast epithelial cells can induce apoptosis of breast cancer cells through insulin-like growth factor-binding protein-3 and maspin.
|
17446556 |
2007 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Apart from SERPINB2 and SERPINB5, the roles of the remaining 13 members of the human SERPINB family in cancer metastasis are still unknown.
|
21993616 |
2012 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Maspin, a tumor suppressor (SERPINB5), inhibits cancer migration, invasion, and metastasis in vitro and in vivo.
|
23924927 |
2013 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Expression of tumor suppressor gene, MASPIN, is associated with inhibition of tumor cell invasion and metastasis.
|
12006534 |
2002 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Thus, SERPINB5 can be used in gene therapy against breast tumor growth and metastasis.
|
12027560 |
2002 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
To investigate whether maspin, when produced at endogenous levels, is capable of inhibiting metastasis to bone we transfected a bacterial artificial chromosome (BAC) genomic clone containing the maspin gene into PC-3 cells that aggressively metastasize to bone in an animal model.
|
18367129 |
2009 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Transfection of MDA-MB-435 mammary carcinoma cells with the maspin gene did not alter the cells' growth properties in vitro, but reduced the cells' ability to induce tumors and metastasize in nude mice and to invade through a basement membrane matrix in vitro.
|
8290962 |
1994 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Finally, engineered alterations in the expression of two of the epithelial genes (SERPINB5 and LTF) modified cell motility in vitro, in accordance with a possible causal role in metastasis.
|
17952122 |
2008 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
CTD_human |
Candidate therapeutic agents for hepatocellular cancer can be identified from phenotype-associated gene expression signatures.
|
19514085 |
2009 |
|
Colorectal Carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer.
|
16331619 |
2006 |
|
Malignant tumor of colon
|
0.310 |
Biomarker
|
disease |
CTD_human |
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
15059925 |
2004 |
|
Colonic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
15059925 |
2004 |
|
Colonic Neoplasms
|
0.310 |
Biomarker
|
group |
BEFREE |
It has been suggested that nuclear expression of maspin (mammary serine protease inhibitor; also known as SERPINB5) in colorectal cancer (CRC) is associated with proximal colonic tumor location, mucinous and poorly differentiated histology, microsatellite instability-high (MSI-H), and poor prognosis.
|
25973084 |
2015 |
|
Invasive Ductal Breast Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines.
|
19944674 |
2010 |
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer.
|
16331619 |
2006 |
|
Mammary Ductal Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines.
|
19944674 |
2010 |
|
Keloid
|
0.300 |
Biomarker
|
disease |
CTD_human |
Comparative proteomic analysis between normal skin and keloid scar.
|
20128793 |
2010 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation.
|
16799634 |
2007 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation.
|
16799634 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, there was 290-fold increase in SERPINB5, a tumor suppressor gene, and a 10-fold higher expression of KISS1, a metastasis suppressor gene, in the treated group.
|
21606571 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KRT16, HOXA10, CDX1, SI, and SERPINB5 in tumors is confirmed by RT-PCR in 20 additional tissues.
|
28418924 |
2017 |