|
Breast Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer.
|
12220518 |
2002 |
|
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To test the therapeutic value of the maspin gene (SERPINB5) in breast cancer, we established a syngeneic breast tumor metastasis model.
|
12027560 |
2002 |
|
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To test the therapeutic value of the maspin gene (SERPINB5) in breast cancer, we established a syngeneic breast tumor metastasis model.
|
12027560 |
2002 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Toward re-expressing tumor suppresor gene maspin in breast cancer.
|
12533266 |
2002 |
|
Mammary Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer.
|
12220518 |
2002 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Reverse-transcriptase polymerase chain reaction of the maspin gene in the detection of bone marrow breast carcinoma cell contamination.
|
11596016 |
2001 |
|
Malignant neoplasm of breast
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
In contrast, 7 of 9 breast cancer cell lines had no detectable maspin expression and 6 of these 7 maspin-negative breast cancer cell lines also displayed an aberrant pattern of cytosine methylation of the maspin promoter.
|
10709100 |
2000 |
|
Breast Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
In contrast, 7 of 9 breast cancer cell lines had no detectable maspin expression and 6 of these 7 maspin-negative breast cancer cell lines also displayed an aberrant pattern of cytosine methylation of the maspin promoter.
|
10709100 |
2000 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We report here a rapid and robust induction of maspin expression in prostate cancer cells (LNCaP, DU145, and PC3) and breast tumor cells (MCF7) following wild type p53 expression from an adenovirus p53 expression vector (AdWTp53). p53 activates the maspin promoter by binding directly to the p53 consensus-binding site present in the maspin promoter.
|
10692390 |
2000 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Maspin, a tumor suppressor (SERPINB5), inhibits cancer migration, invasion, and metastasis in vitro and in vivo.
|
23924927 |
2013 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Apart from SERPINB2 and SERPINB5, the roles of the remaining 13 members of the human SERPINB family in cancer metastasis are still unknown.
|
21993616 |
2012 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Notably, there was 290-fold increase in SERPINB5, a tumor suppressor gene, and a 10-fold higher expression of KISS1, a metastasis suppressor gene, in the treated group.
|
21606571 |
2011 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Of the investigated metastasis suppressor genes, only higher AKAP12 mRNA expression was correlated with decreased metastasis (P < 0.05) and invasion scores (P < 0.01) while higher SERPINB5 mRNA expression was correlated with increased metastasis scores (P < 0.05).
|
20939879 |
2010 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
To investigate whether maspin, when produced at endogenous levels, is capable of inhibiting metastasis to bone we transfected a bacterial artificial chromosome (BAC) genomic clone containing the maspin gene into PC-3 cells that aggressively metastasize to bone in an animal model.
|
18367129 |
2009 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
CTD_human |
Candidate therapeutic agents for hepatocellular cancer can be identified from phenotype-associated gene expression signatures.
|
19514085 |
2009 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Finally, engineered alterations in the expression of two of the epithelial genes (SERPINB5 and LTF) modified cell motility in vitro, in accordance with a possible causal role in metastasis.
|
17952122 |
2008 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Expression of tumor suppressor gene, MASPIN, is associated with inhibition of tumor cell invasion and metastasis.
|
12006534 |
2002 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Thus, SERPINB5 can be used in gene therapy against breast tumor growth and metastasis.
|
12027560 |
2002 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Transfection of MDA-MB-435 mammary carcinoma cells with the maspin gene did not alter the cells' growth properties in vitro, but reduced the cells' ability to induce tumors and metastasize in nude mice and to invade through a basement membrane matrix in vitro.
|
8290962 |
1994 |
|
Colorectal Carcinoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Here, we evaluated maspin protein expression status by immunohistochemistry in 216 MSI-H CRCs.
|
25973084 |
2015 |
|
Colorectal Carcinoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Tissue expression of serpin B5 in 377 patients with CRC was significantly associated with serum CEA, histological grade, stage, lymph node metastasis, lymphatic and perineural invasion, and infiltrative border.
|
24114705 |
2014 |
|
Colorectal Carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer.
|
16331619 |
2006 |
|
Colonic Neoplasms
|
0.310 |
Biomarker
|
group |
BEFREE |
It has been suggested that nuclear expression of maspin (mammary serine protease inhibitor; also known as SERPINB5) in colorectal cancer (CRC) is associated with proximal colonic tumor location, mucinous and poorly differentiated histology, microsatellite instability-high (MSI-H), and poor prognosis.
|
25973084 |
2015 |
|
Malignant tumor of colon
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis and ELISAs revealed significant positive correlations between levels of serpin B5 and CEA in human colon cancer cell lines and in the blood of patients with CRC.
|
24114705 |
2014 |
|
Invasive Ductal Breast Carcinoma
|
0.310 |
PosttranslationalModification
|
disease |
BEFREE |
Clinical significance of Maspin promoter methylation and loss of its protein expression in invasive ductal breast carcinoma: correlation with VEGF-A and MTA1 expression.
|
20697987 |
2011 |