|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Maspin (SerpinB5) is an epithelial-specific tumor suppressor gene product that displays context-dependent cellular functions.
|
27923833 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transfection of MDA-MB-435 mammary carcinoma cells with the maspin gene did not alter the cells' growth properties in vitro, but reduced the cells' ability to induce tumors and metastasize in nude mice and to invade through a basement membrane matrix in vitro.
|
8290962 |
1994 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The maspin gene functions as a tumor suppressor in human breasts, and its expression is frequently lost during breast cancer progression.
|
15256060 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Serpin B5 is a candidate tumour suppressor, but its oncogenic activity has also been reported.
|
24114705 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, genistein decreased DNA methylation in the promoter region of multiple tumor suppressor genes (TSGs) such as ataxia telangiectasia mutated (ATM), adenomatous polyposis coli (APC), phosphatase and tensin homolog (PTEN), mammary serpin peptidase inhibitor (SERPINB5), and increased the mRNA expression of these genes.
|
24532317 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The human maspin gene encodes a protein in the serine proteinase inhibitor (serpin) family with tumor-suppressing functions in cell culture and in nude mice.
|
9132279 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this work, we have investigated the ability of Artificial Transcription Factors (ATFs) to reactivate MASPIN expression and to reduce tumor growth and metastatic dissemination in Non-Small Cell Lung Carcinoma (NSCLC) cell lines carrying a hypermethylated MASPIN promoter.
|
20948306 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Human SERPINB5, commonly known as maspin, has diverse functions as a tumor suppressor.
|
22962304 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of a number of other genes that are strongly and specifically expressed in tumour over normal lung, including SERPINB5, TERT and PRAME, showed marked allelic expression imbalances in the tumour tissue in the context of balanced or only marginally imbalanced relative allelic copy numbers.
|
16222316 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Such inhibition is mediated by SERPINB5 transgene through increased apoptosis in SERPINB5-treated tumors.
|
12027560 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Maspin, a tumor suppressor (SERPINB5), inhibits cancer migration, invasion, and metastasis in vitro and in vivo.
|
23924927 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This paper provides evidence that recombinant maspin protein itself inhibits invasion, and supports the role of maspin as a tumor suppressor.
|
7983035 |
1994 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated SERPINB5 for its impact on PDAC tumor biology and its use as a diagnostic marker for PDAC in the setting of pancreatitis.
|
26646275 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
METABIRC and TCGA breast cancer cohort mRNA expression data analysis revealed that a high expression of the anti‑angiogenesis‑associated genes, THBS2, SERPINF1 and serpin family B member 5 (SERPINB5), and of the tumor suppressor gene, PTEN, was associated with a better overall survival (OS) of breast cancer patients.
|
31059004 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This paper provides evidence that recombinant maspin protein itself inhibits invasion, and supports the role of maspin as a tumor suppressor.
|
7983035 |
1994 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
<b>Results:</b> High immunoreactivity of SERPINB5 was significantly linked to pre- and post-CCRT advanced disease, lymphovascular invasion, and poor response to CCRT (all <i>P</i> ≤ 0.015).
|
29511373 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
<i>Celastrus orbiculatus</i> extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells.
|
29387218 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Expression of tumor suppressor gene, MASPIN, is associated with inhibition of tumor cell invasion and metastasis.
|
12006534 |
2002 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Apart from SERPINB2 and SERPINB5, the roles of the remaining 13 members of the human SERPINB family in cancer metastasis are still unknown.
|
21993616 |
2012 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In addition, serpin B5 and calretinin appear to be candidate biomarkers that may be accessible in patients for monitoring of cancer therapy with ease.
|
23151231 |
2013 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
However, MASPIN protein was 6 times more likely to be detected in cancer specimens that harbor a p53 mutation relative to cancer specimens with a wt p53 gene.
|
21903246 |
2011 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Despite the significant incidence of head and neck SCC (HNSCC), a limited number of studies has considered MASPIN's role in these malignancies.
|
18615330 |
2009 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
In addition, serpin B5 and calretinin appear to be candidate biomarkers that may be accessible in patients for monitoring of cancer therapy with ease.
|
23151231 |
2013 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
Apart from SERPINB2 and SERPINB5, the roles of the remaining 13 members of the human SERPINB family in cancer metastasis are still unknown.
|
21993616 |
2012 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
However, MASPIN protein was 6 times more likely to be detected in cancer specimens that harbor a p53 mutation relative to cancer specimens with a wt p53 gene.
|
21903246 |
2011 |