|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we found that SERPINE2 was increased in ESCC and associated with tumor metastasis.
|
31730904 |
2020 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Integration, through the use of Bayesian colocalization analysis, of publicly available GWAS summary statistics with the cytokine network associations revealed shared causal variants between the eight cytokine loci and other traits; in particular, cytokine network variants at the ABO, SERPINE2, and ZFPM2 loci showed pleiotropic effects on the production of immune-related proteins, on metabolic traits such as lipoprotein and lipid levels, on blood-cell-related traits such as platelet count, and on disease traits such as coronary artery disease and type 2 diabetes.
|
31679650 |
2019 |
|
Coronary heart disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Integration, through the use of Bayesian colocalization analysis, of publicly available GWAS summary statistics with the cytokine network associations revealed shared causal variants between the eight cytokine loci and other traits; in particular, cytokine network variants at the ABO, SERPINE2, and ZFPM2 loci showed pleiotropic effects on the production of immune-related proteins, on metabolic traits such as lipoprotein and lipid levels, on blood-cell-related traits such as platelet count, and on disease traits such as coronary artery disease and type 2 diabetes.
|
31679650 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Integration, through the use of Bayesian colocalization analysis, of publicly available GWAS summary statistics with the cytokine network associations revealed shared causal variants between the eight cytokine loci and other traits; in particular, cytokine network variants at the ABO, SERPINE2, and ZFPM2 loci showed pleiotropic effects on the production of immune-related proteins, on metabolic traits such as lipoprotein and lipid levels, on blood-cell-related traits such as platelet count, and on disease traits such as coronary artery disease and type 2 diabetes.
|
31679650 |
2019 |
|
Hemophilia A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thromboelastometry studies showed enhanced clot stability and lengthened clot lysis time in blood from F8-/-/PN-1-/- and from patients with hemophilia A incubated with a PN-1-neutralizing antibody compared with their respective controls.
|
31383642 |
2019 |
|
Hydronephrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
All potentially prognostic factors were assessed on univariate analyses, which revealed the following factors as being associated with higher risk of early death within 1 year after RARC: older age (P = 0.004), advanced clinical stage (P = 0.005), presence of hydronephrosis (P = 0.021), higher fibrinogen (P = 0.007), higher PLR (P = 0.031), and lower PNI (P = 0.016).
|
31091022 |
2019 |
|
Solid Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Circ-SERPINE2 repressed solid tumour growth through enhancing miR-375 expression and reducing YWHAZ expression in vivo.
|
31199037 |
2019 |
|
Squamous cell carcinoma of mouth
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IHC quantification of p-EMT in OCSCC primary tumors is reliably associated with nodal metastasis, PNI, and high grade.
|
31704557 |
2019 |
|
Hemophilia, NOS
|
0.010 |
Biomarker
|
disease |
BEFREE |
By using the calibrated automated thrombin generation assay, we showed that a PN-1-neutralizing antibody could significantly shorten the thrombin burst in response to tissue factor in platelet-rich plasma (PRP) from patients with mild or moderate hemophilia.
|
31383642 |
2019 |
|
Postoperative pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of these factors, the combination of PNI and ECOG-PS clearly stratified patients into low-, intermediate-, and high-risk groups with respect to developing postoperative pneumonia (area under the curve: 0.709).
|
31712912 |
2019 |
|
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Integration, through the use of Bayesian colocalization analysis, of publicly available GWAS summary statistics with the cytokine network associations revealed shared causal variants between the eight cytokine loci and other traits; in particular, cytokine network variants at the ABO, SERPINE2, and ZFPM2 loci showed pleiotropic effects on the production of immune-related proteins, on metabolic traits such as lipoprotein and lipid levels, on blood-cell-related traits such as platelet count, and on disease traits such as coronary artery disease and type 2 diabetes.
|
31679650 |
2019 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
SERPINE2 is identified most abundantly in adenocarcinomas.
|
29556291 |
2018 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to evaluate the association between O-PNI and surgical outcome during surgery for ulcerative colitis (UC).
|
29270654 |
2018 |
|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data demonstrate that prevention of thrombin signaling by PN-1 constitutes an important endogenous mechanism of protection against lung fibrosis and associated mortality.
|
30254103 |
2018 |
|
Diabetic peripheral neuropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MiR-199a-3p over-expression induced coagulative cascade, swelling and pain by a down-regulation of SERPIN-E2 in diabetic peripheral neuropathy.
|
30190170 |
2018 |
|
Diabetic Neuropathies
|
0.010 |
AlteredExpression
|
group |
BEFREE |
miR‑199a‑3p is involved in the pathogenesis and progression of diabetic neuropathy through downregulation of SerpinE2.
|
28677735 |
2017 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The SMI strongly correlated with sex, body weight, albumin level, and O-PNI in IBD patients.
|
28644887 |
2017 |
|
Narcissism
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Journal of Clinical Child and Adolescent Psychology, 32, 139-152) and PNI grandiose narcissism did not significantly impact this relation.
|
27135438 |
2017 |
|
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results indicate that SERPINE2 and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.
|
28255192 |
2017 |
|
Malnutrition
|
0.010 |
Biomarker
|
disease |
BEFREE |
PNI-O and NRI are the most consistent methods to identify malnutrition in these patients.
|
28549896 |
2017 |
|
Antisocial behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Findings from the two studies revealed that psychopathy-linked narcissism as assessed by the Antisocial Process Screening Device (APSD; Frick & Hare, 2001; Antisocial process screening device.Toronto: Multi-Health Systems.) and vulnerable narcissism as assessed using the Pathological Narcissism Inventory (PNI; Pincus et al., 2009; Initial construction and validation of the Pathological Narcissism Inventory.
|
27135438 |
2017 |
|
Papillary thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Significantly higher concentrations of SERPINE2 and SLPI were found in patients with PTC as compared with MNG and controls.
|
28255192 |
2017 |
|
Malignant neoplasm of stomach stage IV
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mGPS was a more useful prognostic factor than the PNI, NLR, PLR and CONUT in patients undergoing non-curative surgery for stage IV gastric cancer.
|
28739709 |
2017 |
|
Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The cell cycle‑related genes, cyclin‑dependent kinase (CDK)4 and cyclin D1 were positively correlated with SerpinE2 expression in patient‑derived tissue and in osteosarcoma cells.
|
27221371 |
2016 |
|
Intervertebral Disc Degeneration
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of both PN-1 mRNA and protein was significantly decreased in degenerated IVD, and the expression levels of PN-1 were correlated with the grade of disc degeneration.
|
27460424 |
2016 |