|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
X-linked inhibitor of apoptosis protein inhibitor Embelin induces apoptosis via PI3K/Akt pathway and inhibits invasion in osteosarcoma cells.
|
30249882 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRCA1-Associated Protein-1 Suppresses Osteosarcoma Cell Proliferation and Migration Through Regulation PI3K/Akt Pathway.
|
28256910 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A panel of inhibitors of PI3K and Akt treated osteosarcoma cells and blocked kinase activity.
|
29213214 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, the current study reveals that aclidinium bromide might inhibit osteosarcoma cell growth by regulating the PI3K/AKT signaling pathway, which suggests aclidinium bromide is a potential chemotherapeutic agent for osteosarcoma.
|
30657552 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, FAK, PI3K, Akt and NF-κB activation were also shown to be involved in CTGF-mediated osteosarcoma metastasis.
|
29909077 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Western blot analyses revealed that circ-0001785 regulated the PI3K/Akt signaling and Bcl-2 family pathway in osteosarcoma.
|
31116090 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIX1 promoted the progression of osteosarcoma via regulating PTEN/PI3K/AKT signaling cascade, which might provide a new potent therapeutic target for osteosarcoma.
|
29807230 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PIK3CA and AKT gene polymorphisms in susceptibility to osteosarcoma in a Chinese population.
|
24175786 |
2013 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fractalkine induced cell migration by upregulating intercellular adhesion molecule-1 (ICAM-1) expression via CX3CR1/PI3K/Akt/NF-κB pathway in human osteosarcoma cells.
|
28903329 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functional analysis suggests that these lncRNAs were related to the PI3K-Akt signaling pathway, the Wnt signaling pathway, and the G-protein coupled receptor signaling pathway, all of which have various, important roles in osteosarcoma development.
|
31850493 |
2020 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells.
|
31000382 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that CD20, MCM, and CCNB1 (down-regulated) in cell cycle and ECM, ITGA, RTKin (up-regulated) in focal adhesion had important roles in the progression of osteosarcoma.
|
27314445 |
2016 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Biological pathways implicated in osteosarcoma biology through genetic and other preclinical studies include PI3K/mTOR, WNT/βcatenin, TGFβ, RANKL/NF-κB, and IGF.
|
29435436 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
K-Ras<sup>G12V/Y40C</sup>-PI3K/AKT pathway regulates H1.4<sup>S35ph</sup> through PKA to promote the occurrence and development of osteosarcoma cancer.
|
31126199 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, we further found that those effects on osteosarcoma by NRSN2 are associated with the dysregulated PI3K/AKT/mTOR signaling and Wnt/β-catenin signaling.
|
28401012 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lastly, we showed that activation of the PI3K/AKT signal pathway is essential for the effects of ZIC2 on osteosarcoma cells, as the effects of ZIC2 on the osteosarcoma cells were reversed by a PI3K/AKT inhibitor.
|
28857346 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of the signalling relationships of these genes, as well as other expression markers of osteosarcoma, indicated that gene networks linked to RB1, TP53, PI3K, PTEN/Akt, myc and RECQL4 are associated with osteosarcoma.
|
24835790 |
2014 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A panel of inhibitors of PI3K and Akt treated osteosarcoma cells and blocked kinase activity.
|
28289332 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells.
|
28623712 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Honokiol suppresses proliferation and induces apoptosis via regulation of the miR‑21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells.
|
29393336 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.
|
30182951 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the FASN/HER2/PI3K/Akt signaling pathway may be a potential therapeutic target for OS management.
|
28565856 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The activation of PI3K/Akt and the overexpression of fatty acid synthase (FASN) are frequently observed in human osteosarcoma (OS).
|
24366211 |
2014 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway.
|
28932123 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that hBMSC-MVs promoted U2OS cell proliferation and migration under hypoxia in vitro, and that was partially associated with the PI3K/AKT and HIF-1α pathways.
|
30506278 |
2019 |