Childhood Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this largest mutational profiling of osteosarcoma to date, the authors identified for the first time several mutations involving the PI3K pathway, adding osteosarcoma to the growing list of malignancies with PI3K mutations.
|
22006429 |
2012 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we detected a time-dependent decrease in VEGF expression and considerably reduced phosphoinositide 3-kinase (PI3K) and protein kinase B (AKT) activation in osteosarcoma cells treated by Eag1 shRNA.
|
23202914 |
2012 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hsp90B1 is a direct target of miR-223 and miR- 223 may have a tumor suppressor function in osteosarcoma through the PI3K/Akt/mTOR pathway and could be used in anticancer therapies in osteosarcoma.
|
23208072 |
2012 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma.
|
23372675 |
2013 |
Childhood Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PIK3CA and AKT gene polymorphisms in susceptibility to osteosarcoma in a Chinese population.
|
24175786 |
2013 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The activation of PI3K/Akt and the overexpression of fatty acid synthase (FASN) are frequently observed in human osteosarcoma (OS).
|
24366211 |
2014 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of PI3K/Akt/mTORC1 signaling may be effective in osteosarcoma, but further studies are required to determine whether this pathway is active in a substantial subgroup of this heterogeneous tumor.
|
24447333 |
2014 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that TGF-α/EGFR interaction elicits PI3K and Akt activation, which in turn activates NF-κB, resulting in the expression of ICAM-1 and contributing the migration of human osteosarcoma cells.
|
24685520 |
2014 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of the signalling relationships of these genes, as well as other expression markers of osteosarcoma, indicated that gene networks linked to RB1, TP53, PI3K, PTEN/Akt, myc and RECQL4 are associated with osteosarcoma.
|
24835790 |
2014 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, whether the malignant phenotype of osteosarcoma (OS) cells is regulated by the PI3K/Akt/FASN signaling pathway and how the PI3K family specific inhibitor, 2‑(4‑morpholinyl)‑8‑phenyl‑chromone (LY294002) affects the malignant phenotype of OS cells remains to be elucidated.
|
25351625 |
2015 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Osteosarcoma cell lines are responsive to pharmacologic and genetic inhibition of the PI3K/mTOR pathway both in vitro and in vivo.
|
25512523 |
2014 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells through down-regulation of the MDR1 and the PI3K/Akt pathway, and has the potential to be an adjunct to chemotherapy for osteosarcoma.
|
25747987 |
2015 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rationale combinations of specific PI3K and mTOR inhibitors could recapitulate the effect on osteosarcoma cell cultures.
|
25862761 |
2015 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results demonstrate that miR-375 functions as a growth-suppressive miRNA and plays an important role in inhibiting the tumorigenesis through targeting PIK3CA in osteosarcoma.
|
26036761 |
2015 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of IRX2 promoted the activation of PI3K/Akt and increased the proliferation and invasiveness of the OS cell lines as shown by CCK8 and invasion assays.
|
26062523 |
2015 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on the above results, we conclude that PTEN/PI3K/Akt signaling is involved in the inhibitory effect on human OS 143B cell proliferation by EVO.
|
26135006 |
2015 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aplasia Ras homologue member Ⅰ overexpression inhibits tumor growth and induces apoptosis through inhibition of PI3K/Akt survival pathways in human osteosarcoma MG-63 cells in culture.
|
26165148 |
2015 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that miR-497 modulates the sensitivity to cisplatin at least in part through PI3K/Akt pathway in osteosarcoma cells.
|
26202364 |
2015 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We determined that AREG increases the expression of intercellular adhesion molecule-1 (ICAM-1) through PI3K/Akt signaling pathway via its interaction with the epidermal growth factor receptor, thus resulting in the enhanced cell migration of osteosarcoma.
|
26503469 |
2015 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, XBP1 is up-regulated and has a pro-tumor effect in OS with activation of PI3K/mTOR signaling.
|
26633383 |
2015 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that CD20, MCM, and CCNB1 (down-regulated) in cell cycle and ECM, ITGA, RTKin (up-regulated) in focal adhesion had important roles in the progression of osteosarcoma.
|
27314445 |
2016 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also found that the activations of phosphoinositide 3-kinase (PI3K) and protein kinase B (AKT) were considerably reduced after osteosarcoma cells were treated with Lv-shVEGF.
|
27352347 |
2015 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that galangin suppresses osteosarcoma cells by inhibiting their proliferation and invasion and accelerating their apoptosis, and the mechanism may be associated with the inhibition of PI3K and its downstream signaling pathway.
|
27840963 |
2017 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, our data demonstrated that downregulation of HOXB7 inhibited proliferation, invasion, and tumorigenesis, partly through suppressing the PI3K/Akt signaling pathway in osteosarcoma cells.
|
27983923 |
2017 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also found that the PI3K/Akt signaling pathway was involved in the tumor-promoting effect of USP22 on OS progression.
|
27983930 |
2017 |