|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A molecular sub-cluster of colon cancer cells with low VDR expression is sensitive to chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors treatment.
|
31596728 |
2019 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
We showed that PL displayed potent antineoplastic activity against colon cancer cell growth by targeting Ras proteins and PI3K/Akt signaling cascade.
|
30551398 |
2019 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Omentin-1 could inhibit the proliferation and promote apoptosis of colon cancer stem cells in vitro via the PI3K/Akt pathway.
|
30941956 |
2019 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We eventually investigated activation of PI3K/Akt signaling by CXCL12 regulate PTEN and involved in the metastatic process of colon cancer.
|
31500630 |
2019 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Applied to a novel perturbation dataset on PI3K and MAPK pathways in isogenic models of a colon cancer cell line, it generates plausible network hypotheses that explain distinct sensitivities toward various targeted inhibitors due to different PI3K mutants.
|
31510692 |
2019 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacological Inhibition of Casein Kinase 2 Enhances the Effectiveness of PI3K Inhibition in Colon Cancer Cells.
|
30396937 |
2018 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway.
|
30195873 |
2018 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
COMP promoted colon cancer cell proliferation partially through the activation of PI3K/ Akt/ mTOR/ p70S6K pathway.
|
29560517 |
2018 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Meanwhile, our results also demonstrated that silencing of Linc00659 expression leads to cell growth inhibition and induced apoptosis, possibly by suppressing PI3K-AKT signaling in colon cancer.
|
29523145 |
2018 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
CXCL12 gene silencing down-regulates metastatic potential via blockage of MAPK/PI3K/AP-1 signaling pathway in colon cancer.
|
29305742 |
2018 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this view, this study aims to explore the function of FBXL5 in the progression of colon cancer and determine if PI3K/AKT signaling pathway involves in this process.
|
30257389 |
2018 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, selective targeting of oncogenic MAPK-PI3K hub in colon cancer has remained highly challenging, hence it has mostly been unexplored.
|
30023564 |
2017 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
The PI3K/Akt/mTOR pathway plays a crucial role in the pathogenesis of colon cancer.
|
28979133 |
2017 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data also suggested that the PI3K/AKT signaling pathway links PRDX2 with 5-FU-induced apoptosis in colon cancer.
|
28432271 |
2017 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to investigate the role of chemokine (C-X-C motif) ligand 8 (CXCL8) in the proliferation, invasiveness and metastasis of colon cancer and its role in the induction of epithelial-mesenchymal transition (EMT) via activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/nuclear factor-κB (NF-κB) pathway.
|
28259918 |
2017 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis.
|
28881576 |
2017 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study demonstrated that upregulation of miR-542-3p inhibited the growth and invasion of colon cancer cells through PI3K/AKT/survivin signaling, highlighting a novel therapeutic approach for the treatment of colon cancer.
|
29130099 |
2017 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We eventually investigated activation of PI3K/Akt/mTOR signaling by CXCL12 involved in the metastatic process of colon cancer.
|
28811711 |
2017 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways.
|
28782499 |
2017 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel quinazolinone chalcone derivative induces mitochondrial dependent apoptosis and inhibits PI3K/Akt/mTOR signaling pathway in human colon cancer HCT-116 cells.
|
26615871 |
2016 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, PI3K/Akt and Wnt/β-catenin signaling were involved in secreted PKM2 induced colon cancer cell migration.
|
25732087 |
2015 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell lines) and investigated the dynamic relationship between the 78-kDa glucose-regulatory protein (GRP78) and the phosphoinositide 3-kinase (PI3K)/Akt pathway.
|
26225471 |
2015 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer.
|
25554016 |
2015 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
The PTEN/PI3K/Akt and Wnt/β-catenin signaling pathways are involved in the inhibitory effect of resveratrol on human colon cancer cell proliferation.
|
24756222 |
2014 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have previously described the FCPIK3ca* murine colon cancer model, which expresses a constitutively activated phosphoinositide-3 kinase (PI3K) in the intestinal epithelium.
|
23708654 |
2014 |