|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
PIM-1 kinase is an important target in effective therapeutic interventions of lymphomas, prostate cancer and leukemia.
|
30895980 |
2019 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of PIM family members is oncogenic, exemplified by their ability to induce lymphomas in collaboration with c-Myc.
|
31725895 |
2019 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Based on the up-regulation of the proviral integration site of the Moloney murine leukemia virus (Pim) kinase family (Pim1, 2, and 3) observed in several types of leukemias and lymphomas, the development of pan-Pim inhibitors is an attractive therapeutic strategy.
|
31671637 |
2019 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Pim-1 kinase plays a role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas.
|
25553374 |
2015 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Elevated levels of Pim1 kinase were first discovered in human leukemia and lymphomas.
|
23565217 |
2013 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
As PIM1 encodes a serine/threonine kinase, PIM1 kinase inhibition may be a promising therapy for BCL6/PIM1-positive human lymphomas.
|
22451912 |
2012 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we show that PIM kinase expression can affect the clinical outcome of lymphoma chemotherapy.
|
21859846 |
2011 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas.
|
20515470 |
2010 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Recent studies have demonstrated an activated proliferation profile associated with leg type lymphoma including overexpression of proto-oncogenes PIM1, PIM2, and cMYC, and the transcription factors MUM1 and OCT2.
|
17289214 |
2007 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We analyzed the expression of two proto-oncogenes, pim-1 and c-myc, proto-oncogenes deregulated in some human B cell leukemias and lymphomas, in peripheral blood mononuclear leukocytes (PBML) from BLV-infected PL cows.
|
8847898 |
1996 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Provirus insertion near c-myc, pim-1 or Mlvi-1 occurred both in diploid lymphomas and in tumors with trisomy 15.
|
3021636 |
1986 |